Timing Clinic Visits to Phases of the Menstrual Cycle by Using a Fertility Monitor: The BioCycle Study
Timing Clinic Visits to Phases of the Menstrual Cycle by Using a Fertility Monitor: The BioCycle Study
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DOI：
10.1093/aje/kwn287
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发表时间：
2009-01-01
影响因子：
5
通讯作者：
Hovey, Kathleen M.
中科院分区：
文献类型：
--
作者：
Howards, Penelope P.;Schisterman, Enrique F.;Hovey, Kathleen M.
如果暴露或结果受到荷尔蒙变化的影响，在特定的月经周期阶段计划研究访问是重要的。然而，激素谱在不同的周期和不同的女性之间是不同的。在BioCycle研究(2005-2007)中，评估了使用生育监测器对门诊就诊时间进行计时的价值。在纽约布法罗招募了年龄18-44岁(平均27.4岁)、自我报告的月经周期为21-35天的女性，共2个周期(n=250)。参与者被提供了家庭生育监测器，测量尿中雌酮-3-葡萄糖醛酸化物和黄体生成素(LH)。当监护仪显示黄体生成素激增时，这些妇女被指示去诊所抽血。在第一个周期的76%和第二个周期的78%期间，监测仪记录到了激增。使用设定的周期天数或基于周期长度的算法(如周期中期窗口或通过假设固定的黄体周期长度确定的窗口)来安排来访将会更简单。然而，即使在3天的窗口期内完全出席，这些方法也会表现不佳，只有37%-57%的时间捕捉到监视器检测到的黄体生成素峰值。生育力监测仪似乎在灵活安排时间的顺从人群中安排诊所就诊时间很有用。
Planning study visits during specific menstrual cycle phases is important if the exposure or outcome is influenced by hormonal variation. However, hormone profiles differ across cycles and across women. The value of using fertility monitors to time clinic visits was evaluated in the BioCycle Study (2005-2007). Women aged 18-44 years (mean, 27.4) with self-reported menstrual cycle lengths of 21-35 days were recruited in Buffalo, New York, for 2 cycles (n = 250). Participants were provided with home fertility monitors that measured urinary estrone-3-glucuronide and luteinizing hormone (LH). The women were instructed to visit the clinic for a blood draw when the monitor indicated an LH surge. The monitor recorded a surge during 76% of the first cycles and 78% of the second cycles. Scheduling visits by using set cycle days or algorithms based on cycle length, such as a midcycle window or a window determined by assuming a fixed luteal phase length, would be simpler. However, even with perfect attendance in a 3-day window, these methods would have performed poorly, capturing the monitor-detected LH surge only 37%-57% of the time. Fertility monitors appear to be useful in timing clinic visits in a compliant population with flexible schedules.