Biochemical abnormalities in Huntington's chorea brains
Biochemical abnormalities in Huntington's chorea brains
复制标题
亨廷顿舞蹈症大脑的生化异常
作者：
W. L. Stahl;P. Swanson
三名死于长期亨廷顿舞蹈病的患者的大脑纹状体中的谷氨酸脱羧酶、胆碱乙酰化酶和琥珀酸脱氢酶减少了74%到93%。乙酰胆碱酯酶和单胺氧化酶活性变化不大。在第四例患者的早期病例中，没有酶变化。一种高分子量可溶性蛋白存在于纹状体的先进的情况下，但膜蛋白模式没有从控制不同。
The enzymes glutamic acid decarboxylase, choline acetylase, and succinate dehydrogenase were reduced by 74 to 93 percent in striatum of brains from three patients who died with long-standing Huntington's chorea. Little change was found in acetylcholinesterase or monoamine oxidase activities. In an early case of this disease in a fourth patient, there were no enzymatic changes. A high-molecular-weight soluble protein was present in the striatum of the advanced cases but membrane protein patterns did not differ from those of controls.