COMPARISON OF CONTINUOUS AND SEQUENTIAL ESTROGEN-PROGESTOGEN TREATMENT IN WOMEN WITH CLIMACTERIC SYMPTOMS
COMPARISON OF CONTINUOUS AND SEQUENTIAL ESTROGEN-PROGESTOGEN TREATMENT IN WOMEN WITH CLIMACTERIC SYMPTOMS
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DOI：
10.1016/0378-5122(89)90122-9
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发表时间：
1989-03-01
期刊：
影响因子：
4.9
通讯作者：
SANDVIK, L
中科院分区：
文献类型：
--
作者：
HOVIK, P;SUNDSBAK, HP;SANDVIK, L
在一项随机、平行、分组研究中，对患有更年期症状的妇女进行了连续（Kliogest）和顺序（Trisequens）雌激素-孕激素治疗的比较。受试者接受Trisequens治疗4个月，然后随机分配到2个治疗组中的1个，此后12个月使用Trisequens或Kliogest。这项研究最初招募了41名患者。其中34人完成了研究，因此每个治疗组由17名妇女组成。结果表明，在缓解更年期症状方面，连续治疗与顺序治疗同样有效。黄体生成素（LH）和促卵泡激素（FSH）水平在序贯治疗和连续治疗切换后显著降低（LH: P < 0.001; FSH: P < 0.01）。2名妇女被检测出乳腺癌，每个治疗组1名。两组的体重、血压和胆固醇浓度都没有明显变化。未见子宫内膜增生。在持续治疗组，突破性出血在治疗期开始时出现暂时增加。结论是，持续治疗似乎是治疗气候症状的有效方案，它不会引起每月出血。
Continuous (Kliogest) and sequential (Trisequens) oestrogen-progestogen treatment were compared in a randomized, parallel, group study in women suffering from climacteric symptoms. The subjects were treated with Trisequens for 4 months prior to randomized assignment to 1 of 2 treatment groups, and with either Trisequens or Kliogest for 12 months thereafter. Forty-one (41) patients were initially recruited for the study. Of these, 34 completed the study, each treatment group hence comprised 17 women. The results suggest that continuous treatment is as effective as sequential treatment in alleviating climacteric symptoms. Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were significantly reduced after changeover from sequential to continuous treatment (LH: P < 0.001; FSH: P < 0.01). Breast cancer was detected in 2 women, 1 being from each treatment group. Weight, blood pressure and cholesterol concentrations were not significantly altered in either of the groups. There were no cases of endometrial hyperplasia. In the continuous-treatment group a temporary increase in breakthrough bleeding occurred at the beginning of the treatment period. It was concluded that continuous treatment seems to constitute an efficacious regimen for climateric symptoms, which does not induce monthly bleeding.