Long-term effect of sodium hyaluronate (Hyalgan®) on osteoarthritis progression in a rabbit model
Long-term effect of sodium hyaluronate (Hyalgan®) on osteoarthritis progression in a rabbit model
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DOI：
10.1016/s1063-4584(03)00119-5
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发表时间：
2003-09-01
影响因子：
7
通讯作者：
Healey, RM
中科院分区：
文献类型：
--
作者：
Amiel, D;Toyoguchi, T;Healey, RM
背景：关节内（IA）透明质酸（HA）注射被批准用于治疗膝骨关节炎（OA）疼痛。目前可用的产品之一被批准用于重复治疗课程。虽然 HA 被归类为一种症状缓解剂，但有大量证据表明这种治疗方式也具有缓解疾病的活性。 目的：使用兔 OA 模型（前交叉韧带横断术 (ACLT)）来研究单疗程和连续疗程的 HA 治疗对 OA 进展的长期影响。设计：每周 5 次 IA 注射一个或两个疗程的透明质酸钠 (Hyalgan((R))) 平均分子量，MW， ACLT 后 4 周和 13 周（对于接受第二个疗程的组），对兔子（每组 10 只）给予 500-730 kDa 或媒介物。术后 26 周处死后，对收获的膝关节进行大体形态学和组织形态学评估。 结果：所有兔子均表现出 OA 的特征性病理变化。接受一或两个疗程 HA 注射的兔子比单独接受 ACLT 或接受 10 次载体注射治疗的兔子表现出更少的疾病进展。然而，与未注射的兔子相比，接受五次载体注射的兔子也表现出形态改善。与接受 ACLT、注射 5 次 HA 或注射 10 次媒介物治疗的兔子相比，接受 10 次 HA 注射的兔子股骨软骨表面粗糙度显着降低，并且与所有其他治疗组相比，胫骨平台表面粗糙度显着降低 (P < 0.05)。 结论：重复注射 HA 疗程可减轻兔 ACLT OA 模型的关节退行性变程度。 HA 的连续疗程可能有利于 OA 的长期治疗。 (C) 2003 年由 Elsevier Ltd 代表国际骨关节炎研究协会出版。
Background: Intra-articular (IA) hyaluronan (HA) injections are approved for the treatment of knee osteoarthritis (OA) pain. One of the currently available products is approved for repeat treatment courses. While HA is classed as a symptom-modifying agent, there is substantial evidence that this therapeutic modality also possesses disease-modifying activity.Objective: A rabbit model of OA, anterior cruciate ligament transection (ACLT), was used to investigate the long-term effects of single and sequential courses of HA therapy on OA progression.Design: One or two courses of five weekly IA injections of sodium hyaluronate (Hyalgan((R))) average molecular weight, MW, of 500-730 kDa, or vehicle were administered to rabbits (N = 10 per group), initiated 4 and 13 weeks (for groups that received a second course) after ACLT Gross morphological and histomorphometric evaluations were performed on harvested knee joints following sacrifice at 26 weeks after surgery.Results: All the rabbits exhibited the characteristic pathologic changes of OA. Rabbits that received one or two courses of HA injections showed less disease progression than rabbits treated with ACLT alone or with 10 vehicle injections. However, rabbits that received five vehicle injections also showed improved morphology compared with those given no injections. Rabbits that received 10 HA injections showed significantly less surface roughness of the femoral cartilage compared with rabbits treated with ACLT, 5 HA injections, or 10 vehicle injections, and showed significantly less surface roughness of the tibial plateau compared with all other treatment groups (P < 0.05).Conclusions: Repeat courses of HA injections reduced the degree of articular degeneration in a rabbit ACLT model of OA. Sequential courses of HA therapy may be advantageous in the long-term management of OA. (C) 2003 Published by Elsevier Ltd on behalf of OsteoArthritis Research Society International.