Age-Related Changes of Elastic Fibers in Shoulder Capsule of Patients with Glenohumeral Instability: A Pilot Study.
Age-Related Changes of Elastic Fibers in Shoulder Capsule of Patients with Glenohumeral Instability: A Pilot Study.
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DOI：
10.1155/2018/8961805
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发表时间：
2018
影响因子：
--
通讯作者：
Porcellini G
中科院分区：
文献类型：
--
作者：
Castagna A;Cesari E;Gigante A;Di Matteo B;Garofalo R;Porcellini G
Recurrent shoulder dislocations occur much more frequently in adolescents than in the older population but a clear explanation of this incidence does not exist. The aim of the present study was to define the age-related distribution of the elastic fibers (EFs) in the shoulder capsule's extracellular matrix as a factor influencing shoulder instability. Biopsy specimens were obtained from the shoulder capsule of patients divided preoperatively into three groups: Group 1 consisted of 10 male patients undergoing surgery for unidirectional traumatic anterior instability (TUBS); Group 2 consisted of 10 male patients undergoing surgery for multidirectional instability (MDI); Group 3 represents the control, including 10 patients with no history of instability. In addition to the group as a whole, specific subgroups were analyzed separately on the basis of the age of subjects: > 22 or < to 22 years. All the samples were analyzed by histochemical (Weigert's resorcinol fuchsin and Verhoeff's iron hematoxylin), immunohistochemical (monoclonal antielastin antibody), and histomorphometric methods. Both the elastin density and the percentage of area covered by EFs were significantly higher in younger subjects (<22 years old). Furthermore, the elastin density and the percentage of area covered by EFs were significantly higher in specimens of group of patients affected by multidirectional shoulder instability in comparison to the other two groups. Data of the present study confirmed the presence of an age-related distribution of EFs in the human shoulder capsule. The greater amount of EFs observed in younger subjects and in unstable shoulders could play an important role in predisposing the joint to first dislocation and recurrence.
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影响因子：
5.3
作者：
Porcellini, Giuseppe;Campi, Fabrizio;Paladini, Paolo
通讯作者：
Paladini, Paolo
影响因子：
5.3
作者：
Robinson, C. Michael;Howes, Jonathan;Graham, Catriona
通讯作者：
Graham, Catriona
DOI：
10.2106/00004623-198466020-00001
发表时间：
1984-01-01
影响因子：
5.3
作者：
ROWE, CR;ZARINS, B;CIULLO, JV
通讯作者：
CIULLO, JV
影响因子：
0.3
作者：
Geier, C. David, Jr.;Paletta, George A., Jr.
通讯作者：
Paletta, George A., Jr.
影响因子：
2.8
作者：
Gigante, A;Chillemi, C;Greco, F
通讯作者：
Greco, F