Validation of the QUAL-EC for assessing quality of life in patients with advanced cancer
Validation of the QUAL-EC for assessing quality of life in patients with advanced cancer
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DOI：
10.1016/j.ejca.2010.10.027
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发表时间：
2011-03-01
影响因子：
8.4
通讯作者：
Zimmermann, Camilla
中科院分区：
文献类型：
--
作者：
Lo, Christopher;Burman, Debika;Zimmermann, Camilla
目的：改善生活质量是姑息治疗的主要目标。然而，缺乏专门针对晚期癌症的有效措施。本研究的目的是验证的生命质量在生命结束时（ESTA-E）措施在一个样本中的晚期cancer.Methods：数据进行了分析，为464例晚期癌症患者谁参加了一项随机对照试验的早期姑息治疗干预与常规护理。患者完成了26项癌症治疗功能评估（FACT-G）生活质量测量和精神健康，表现状态，症状负担，护理满意度和与卫生保健提供者的沟通措施。我们进行了验证性因素分析的ESTA-E测试的假设四因素结构和结构效度通过计算相关scales.Results：一个17个项目的ESTA-E，ESTA-E-癌症（ESTA-EC）的简化版本实现了一个可接受的适合四因素模型。完整版和简化版的量表都具有较好的结构效度。症状控制与身体功能的其他指标相关;与医疗保健提供者的关系与护理满意度以及更好的医生和护士沟通相关;为生命结束做准备与情感幸福感密切相关;生命完成与社会和精神幸福感密切相关。由于简化版的生存质量量表具有良好的因子结构和良好的心理测量学特征，我们推荐使用该量表来评估晚期癌症患者的生存质量。(c)2010爱思唯尔有限公司保留所有权利。
Objective: Improving quality of life is the main goal of palliative cancer care. However, there is a lack of measures validated specifically for advanced cancer. The purpose of this study was to validate the Quality of Life at the End of Life (QUAL-E) measure in a sample of patients with advanced cancer.Methods: Data were analysed for 464 patients with advanced cancer who were participating in a randomised controlled trial of early palliative care intervention versus routine care. Patients completed the 26-item QUAL-E, the Functional Assessment of Cancer Therapy (FACT-G) quality of life measure and measures of spiritual well-being, performance status, symptom burden, satisfaction with care and communication with health care providers. We conducted a confirmatory factor analysis on the QUAL-E to test for the hypothesised four-factor structure and examined construct validity by calculating correlations with relevant scales.Results: A 17-item reduced version of the QUAL-E, the QUAL-E-Cancer (QUAL-EC) achieved an acceptable fit to a four-factor model. Both the full and reduced versions of the QUAL-E were internally reliable and showed good construct validity. Symptom Control was correlated with other measures of physical functioning; Relationship with Healthcare Provider was correlated with satisfaction with care and better physician and nurse communication; Preparation for End of Life was strongly associated with emotional well-being; and Life Completion was strongly associated with social and spiritual well-being.Conclusions: Due to its good factor structure and sound psychometrics, we recommend the reduced QUAL-EC scale to assess quality of life in patients with advanced cancer. (c) 2010 Elsevier Ltd. All rights reserved.