Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
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DOI：
10.1086/315215
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发表时间：
2000-01-01
影响因子：
6.4
通讯作者：
Nisalak, A
中科院分区：
文献类型：
--
作者：
Vaughn, DW;Green, S;Nisalak, A
为探讨病毒载量在登革出血热（DHF）发病中的作用，对泰国2所医院168例急性登革病毒感染儿童的连续血浆标本进行了病毒血症滴度检测，并对165例感染者进行了病毒血清型鉴定（DEN-1，46例患者; DEN-2，47例患者; DEN-3，47例患者，DEN-4，25例患者），DEN-2感染的患者比感染其他血清型的患者经历了更严重的疾病，81%的患者经历了与更严重疾病相关的继发性登革病毒感染。测定了41例DEN-1和46例DEN-2患者的病毒血症滴度。较高的峰值滴度与31名患者的疾病严重程度增加相关，具有确定的峰值滴度（登革热患者的平均滴度为10（7.6），DHF患者的平均滴度为10（8.5），P = 0.01），登革热疾病严重程度增加与高病毒血症滴度、继发性登革热病毒感染和DEN-2病毒类型相关。
Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF), The infecting virus serotype was identified for 165 patients (DEN-1, 46 patients; DEN-2, 47 patients; DEN-3, 47 patients, DEN-4, 25 patients), Patients with DEN-2 infections experienced more severe disease than those infected with other serotypes, Eighty-one percent of patients experienced a secondary dengue virus infection that was associated with more severe disease. Viremia titers were determined for 41 DEN-1 and 46 DEN-2 patients. Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified (mean titer of 10(7.6) for those with dengue fever vs. 10(8.5) for patients with DHF, P = .01), Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type.