The Value of Assessment Tests in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Value of Assessment Tests in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
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评估测试对慢性阻塞性肺疾病急性加重患者的价值
DOI：
10.1097/maj.0b013e31829a63b1
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发表时间：
2014-05
影响因子：
3.1
通讯作者：
Wu, Xue-ling
中科院分区：
文献类型：
--
作者：
Zhao, Yun-feng;Jiang, Yan-ping;Zhou, Lin-fu;Wu, Xue-ling
Abstract:The aim of our study was to investigate the chronic obstructive pulmonary disease (COPD) assessment test (CAT), serum copeptin, procalcitonin and C-reactive protein (CRP) levels as potential predictive factors for recurrence of acute exacerbation and all-cause mortality in 6 months of COPD inpatients. One hundred fifty-nine patients who met the inclusion criteria were enrolled and followed up for 6 months. The CAT scores, serum copeptin, procalcitonin and CRP levels were measured on admission and 14 days and 3 months later in all patients. The primary endpoint was recurrence of acute exacerbation in 6 months. The secondary endpoint was all-cause mortality after 6 months. The CAT scores, serum copeptin, procalcitonin and CRP levels were significantly elevated on admission and stabilized at 14 days (P < 0.01). In a univariate logistic regression analysis, CAT scores (odds ratio [OR] = 1.10), forced expiratory volume in 1 second % (OR = 1.01), serum copeptin (OR = 1.32) and CRP levels (OR = 1.01) were significantly related to recurrence of acute exacerbation in 6 months (P < 0.05). In a multivariate logistic regression model, increasing CAT scores (OR = 1.10) and serum copeptin levels (OR = 1.29) were still associated with an increased odds of exacerbation (P < 0.05). In a univariate logistic regression analysis, increasing CAT scores (OR = 1.19), forced expiratory volume in 1 second % (OR = 1.05), serum copeptin levels (OR = 1.44) and hospitalization in the previous years (OR = 1.24) were significant determinants of death over a follow-up period of 6 months (P < 0.05). But only serum copeptin (OR = 1.53) and CAT scores (OR = 1.37) were associated with mortality in multivariate logistic regression analysis. Hence, high CAT scores and serum copeptin levels link with recurrence of acute exacerbation and all-cause mortality during 6 months in patients with acute exacerbation of COPD.
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DOI：
10.1016/s0140-6736(07)61382-8
发表时间：
2007-09-01
期刊：
Lancet (London, England)
影响因子：
--
作者：
Wedzicha JA;Seemungal TA
通讯作者：
Seemungal TA
影响因子：
2.5
作者：
R. Pauwels;A. Buist;P. Ma;C. Jenkins;S. Hurd
通讯作者：
R. Pauwels;A. Buist;P. Ma;C. Jenkins;S. Hurd
影响因子：
5.8
作者：
Katan, Mira;Morgenthaler, Nils G.;Christ-Crain, Mirjam
通讯作者：
Christ-Crain, Mirjam
影响因子：
39.3
作者：
Voors, Adriaan A.;von Haehling, Stephan;Dickstein, Kenneth
通讯作者：
Dickstein, Kenneth
影响因子：
10
作者：
Lin-fu Zhou;Liang Chen;Quan Zhu;Cong Wang;Hai-xia Xu;X. Cui;Lei-fu Jiang;Shao-heng He;Mao Huang;K. Yin
通讯作者：
Lin-fu Zhou;Liang Chen;Quan Zhu;Cong Wang;Hai-xia Xu;X. Cui;Lei-fu Jiang;Shao-heng He;Mao Huang;K. Yin