Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells
Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells
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病毒感染性在流感病毒特异性细胞毒性 T 细胞诱导中的作用
DOI：
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发表时间：
1978
影响因子：
15.3
通讯作者：
K. Yap
中科院分区：
文献类型：
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作者：
T. Braciale;K. Yap
本报告研究了在诱导流感病毒特异性细胞毒性T细胞中对感染性病毒的需求。发现感染性流感病毒在体内产生原发性和继发性细胞毒性T细胞应答方面是高效的。然而，灭活的流感病毒即使在比感染性病毒的最小刺激剂量高10（5）-10（6）倍的免疫剂量下也不能在体内刺激可检测的细胞毒性T细胞应答。同样地，灭活的病毒在体外不能使靶细胞对T细胞介导的裂解敏感，但可以在体外刺激来自致敏细胞的特异性细胞毒性应答。根据这些观察结果和其他研究者的观察结果，讨论了诱导病毒特异性细胞毒性T细胞应答的可能要求。
This report examines the requirement for infectious virus in the induction of influenza virus-specific cytotoxic T cells. Infectious influenza virus was found to be highly efficient at generating both primary and secondary cytotoxic T-cell response in vivo. Inactivated influenza virus however, failed to stimulate a detectable cytotoxic T- cell response in vivo even at immunizing doses 10(5)-10(6)-fold higher than the minimum stimulatory dose of infectious virus. Likewise inactivated virus failed to sensitize target cells for T cell-mediated lysis in vitro but could stimulate a specific cytotoxic response from primed cells in vitro. Possible requirements for the induction of virus- specific cytotoxic T-cell responses are discussed in light of these observations and those of other investigators.