SIMULATION OF BIOLOGICAL CELL SORTING USING A 2-DIMENSIONAL EXTENDED POTTS-MODEL
SIMULATION OF BIOLOGICAL CELL SORTING USING A 2-DIMENSIONAL EXTENDED POTTS-MODEL
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DOI：
10.1103/physrevlett.69.2013
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发表时间：
1992-09-28
影响因子：
8.6
通讯作者：
GLAZIER, JA
中科院分区：
文献类型：
--
作者：
GRANER, F;GLAZIER, JA
我们模拟的两种类型的生物细胞的混合物的分选使用的大Q波茨模型的修改版本与差分粘附性。我们发现长距离的细胞运动导致分选与对数增加的长度规模的均匀集群。分类群集，然后进行舍入。我们发现两个连续的阶段：一个快速的边界驱动创建一个低凝聚力的细胞单层周围的聚集体，和一个较慢的边界无关的内部重排。
We simulate the sorting of a mixture of two types of biological cells using a modified version of the large-Q Potts model with differential adhesivity. We find long-distance cell movement leading to sorting with a logarithmic increase in the length scale of homogeneous clusters. Sorted clusters then round. We find two successive phases: a rapid boundary-driven creation of a low-cohesivity cell monolayer around the aggregate, and a slower boundary-independent internal rearrangement.