Optical coherence tomography angiography assessment of the macular capillary plexus after surgery for macula-off rhegmatogenous retinal detachment.
Optical coherence tomography angiography assessment of the macular capillary plexus after surgery for macula-off rhegmatogenous retinal detachment.
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黄斑脱落孔源性视网膜脱离手术后黄斑毛细血管丛的光学相干断层扫描血管造影评估。
DOI：
10.1007/s00417-018-4133-3
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Nakazawa T.
中科院分区：
文献类型：
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作者：
Yui N;Kunikata H;Aizawa N;Nakazawa T.
黄斑裂孔性视网膜脱离（RRD）是一种即使在成功的视网膜复位后也会导致严重的中心视力障碍的疾病。光学相干断层扫描血管造影术（OCTA）可以测量黄斑毛细血管丛（MCP）中的血管密度（VD），包括表面（SCP）和深层（DCP），并可以测量这些层中的中心凹无血管区（FAZ）。先前的研究使用OCTA评估黄斑关闭RRD眼中FAZ与视力（VA）之间的相关性[1]。在这里，我们通过在SCP和DCP中包括OCTA测量的VD的测量值来扩展先前的结果，并将这些测量值与其他临床结果（包括VA和中心凹厚度（FT））进行比较，以便更详细地研究成功复位黄斑脱离RRD的眼睛中血管变化的意义。纳入27例患者（47.4±16.7岁）的27只眼。所有患者均具有临床可检测到的黄斑脱离RRD，在单次手术中成功治疗，并在术后3个月使用RS-3000（Nidek，Gamagori，Japan）设备在3 mm× 3 mm黄斑区域进行OCTA成像。在以中心凹为中心的直径为2 mm的圆中自动计算VD。SCP定义为内界膜与内网层外缘之间的一层; DCP定义为SCP外缘与外网层外缘之间的一层。根据眼内手术史、Emery-Little 2级或更高透镜核、视神经疾病或其他玻璃体视网膜疾病排除眼睛。表1总结了RRD眼睛的特征以及与VA和FT的相关性。术后3个月SCP VD、SCP FAZ和DCP FAZ与术后3个月FT不相关，但术后3个月DCP VD与术后3个月FT相关（r= 0.60，P= 0.02;图1右下）。术后3个月DCP FAZ、SCP VD和DCP VD与术后3个月VA不相关，但术后3个月SCP FAZ与术后3个月VA相关（r=-0.53，P= 0.02;图1中上部）。此外，SCP和DCP的术后3个月VD与术前VA相关（SCP：r=-0.70，P= 0.001; DCP：r=-0.50，P= 0.04;图1左下）。所有患者均未出现术后黄斑囊样水肿和视网膜前膜。
Dear Editor, Macula-involved rhegmatogenous retinal detachment (RRD) is a condition that can cause severe central visual disturbance, even after successful retinal re-attachment. Optical coherence tomography angiography (OCTA) can measure vessel density (VD) in the macular capillary plexus (MCP), both superficially (the SCP) and deeply (the DCP), and can measure the foveal avascular zone (FAZ) in these layers. Previous research used OCTA to evaluate the correlation between the FAZ and visual acuity (VA) in the eyes with macula-off RRD [1]. Here, we extend previous results by including measurements of OCTA-measured VD in both the SCP and DCP, and compared these measurements with other clinical findings, including VA and foveal thickness (FT), in order to investigate in greater detail the significance of vascular changes in the eyes with successfully reattached macula-off RRD. Twenty-seven eyes of 27 patients (47.4±16.7 years old) were included. All patients had clinically detectable macula-off RRD that was successfully treated in a single surgical procedure and underwent OCTA imaging in a 3 mm× 3 mm macular area using the RS-3000 (Nidek, Gamagori, Japan) device 3-month postoperatively. VD was automatically calculated in a fovea-centered 2-mm-diameter circle. The SCP was defined as the layer between the inner limiting membrane and the outer border of the inner plexiform layer; the DCP was defined as the layer between the outer border of the SCP and the outer border of the outer plexiform layer. Eyes were excluded based on a history of intraocular surgery, an Emery–Little grade 2 or higher lens nucleus, optic nerve disease, or other vitreoretinal disease. Table 1 summarizes the characteristics of the eyes with RRD and the associations with VA and FT. Three-month postoperative SCP VD, SCP FAZ, and DCP FAZ were not correlated with 3-month postoperative FT, but 3-month postoperative DCP VD was correlated with 3-month postoperative FT (r= 0.60, P= 0.02; Fig. 1 bottom right). Three-month postoperative DCP FAZ, SCP VD, and DCP VD were not correlated with 3-month postoperative VA, but 3-month postoperative SCP FAZ was correlated with 3-month postoperative VA (r=-0.53, P= 0.02; Fig. 1 top middle). Furthermore, 3-month postoperative VD in both the SCP and DCP was correlated with preoperative VA (SCP: r=-0.70, P= 0.001; DCP: r=-0.50, P= 0.04; Fig. 1 bottom left). None of the patients were affected by postoperative cystoid macular edema and epiretinal membrane.