Forward Problem of Electrocardiography Is It Solved?
Forward Problem of Electrocardiography Is It Solved?
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DOI：
10.1161/circep.114.001573
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发表时间：
2015-06-01
影响因子：
8.4
通讯作者：
Smaill, Bruce H.
中科院分区：
文献类型：
--
作者：
Bear, Laura R.;Cheng, Leo K.;Smaill, Bruce H.
背景：心外膜和体表电位之间的关系决定了心电图学的正问题。一个稳健的正问题公式有助于解决逆问题，在逆问题中，心外膜电位是根据已知的体表电位计算的。方法和结果麻醉开胸猪(n=5)在窦性心律、心外膜和心内膜起搏(共65条记录)下同时记录体表和心外膜电位。使用磁共振成像构建的实验特定体积导体模型，从心外膜记录模拟体表电位。将均匀(各向同性电特性)和非均匀(包括肺、各向异性骨骼肌和皮下脂肪)正向模型的结果与测量的体表电位进行比较。所有动物和激活序列的相关系数为0.850.08，均相溶液和非均相溶液之间没有显著差异(P=0.85)。尽管如此，模拟的体表电势分布与测量的体表电势分布仍有相当大的差异。均匀正演模型预测的体表电位极值与观测值之间的差异为55%~78%(P
Background The relationship between epicardial and body surface potentials defines the forward problem of electrocardiography. A robust formulation of the forward problem is instrumental to solving the inverse problem, in which epicardial potentials are computed from known body surface potentials. Here, the accuracy of different forward models has been evaluated experimentally.Methods and Results Body surface and epicardial potentials were recorded simultaneously in anesthetized closed-chest pigs (n=5) during sinus rhythm, and epicardial and endocardial ventricular pacing (65 records in total). Body surface potentials were simulated from epicardial recordings using experiment-specific volume conductor models constructed from magnetic resonance imaging. Results for homogeneous (isotropic electric properties) and inhomogeneous (incorporating lungs, anisotropic skeletal muscle, and subcutaneous fat) forward models were compared with measured body surface potentials. Correlation coefficients were 0.850.08 across all animals and activation sequences with no significant difference between homogeneous and inhomogeneous solutions (P=0.85). Despite this, there was considerable variance between simulated and measured body surface potential distributions. Differences between the body surface potential extrema predicted with homogeneous forward models were 55% to 78% greater than observed (P