Generic and specific measurement of health-related quality of life in a clinical trial of respiratory rehabilitation
Generic and specific measurement of health-related quality of life in a clinical trial of respiratory rehabilitation
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DOI：
10.1016/s0895-4356(98)00157-7
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发表时间：
1999-03-01
影响因子：
7.2
通讯作者：
Goldstein, RS
中科院分区：
文献类型：
--
作者：
Guyatt, GH;King, DR;Goldstein, RS
本研究的目的是比较慢性气流受限患者呼吸康复与传统社区护理的随机对照试验中健康相关生活质量指标的表现。该研究纳入了89名中度至重度慢性气流受限的稳定患者，并在12周，18周和24周测量了健康状况。结果包括两个疾病特异性（氧气成本图和慢性呼吸问卷[CRQ]）措施，一个通用的健康概况（疾病影响概况[SIP]），和两个效用措施（标准赌博和幸福指数[QWB]）。在这些指标中，只有CRQ的四个领域（呼吸困难、疲劳、掌握和情绪功能）在治疗组和对照组之间显示出统计学显著性差异（P小于或等于0.05）。CRQ变化与其他相关指标变化之间的相关性，包括6分钟步行试验和呼吸困难、疲劳和情绪功能变化的总体评分，通常为弱至中度（从0.19至0.51）。QWB、SIP和Standard Gamble与其他指标的变化之间的所有相关性都非常弱或很弱（高达0.30）。三项通用指标变化之间的相关性都很弱（
The purpose of this study was to compare the performance of measures of health-related quality of life in a randomized controlled trial of respiratory rehabilitation versus conventional community care for patients with chronic airflow limitation. The study included 89 stable patients with moderate to severe chronic airflow limitation with measurement of health status at 12, 18, and 24 weeks. Outcomes included two disease-specific (the Oxygen Cost Diagram and the Chronic Respiratory Questionnaire [CRQ]) measures, a generic health profile (the Sickness Impact Profile [SIP]), and two utility measures (the Standard Gamble and the Quality of Well-Being index [QWB]). Of the measures, only the four domains of the CRQ (dyspnea, fatigue, mastery, and emotional function) showed statistically significant differences (P less than or equal to 0.05) between treatment and control groups. Correlation between change in the CRQ and change in other relevant measures, including the 6-minute walk test and global ratings of change in dyspnea, fatigue, and emotional function were generally weak to moderate (from 0.19 to 0.51). All correlations between change in the QWB, SIP, and Standard Gamble and other measures were very weak or weak (up to 0.30). Correlation between change in the three generic measures were all very weak (