SUSCEPTIBILITY TO PILOCARPINE-INDUCED SEIZURES IN RATS INCREASES WITH AGE
SUSCEPTIBILITY TO PILOCARPINE-INDUCED SEIZURES IN RATS INCREASES WITH AGE
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DOI：
10.1016/0166-4328(88)90019-8
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发表时间：
1988-12-01
影响因子：
2.7
通讯作者：
FINE, A
中科院分区：
文献类型：
--
作者：
PATEL, S;MELDRUM, BS;FINE, A
全身给予高剂量的胆碱能激动剂毛果芸香碱诱导大鼠运动边缘癫痫发作。在成年期，对匹鲁卡品惊厥作用的敏感性增加：全身性癫痫发作的阈值剂量从30至70天基本不变，但此后降低，特别是超过100天。癫痫易感性的增加持续到至少200天（研究的最大年龄）。
Systemic administration of high doses of the cholinergic agonist pilocarpine induces motor limbic seizures in rats. Susceptibility to the convulsant effects of pilocarpine increases during adult life: the threshold dose for generalized seizures is essentially constant from age 30 to 70 days, but decreases thereafter, particularly beyond age 100 days. The increase in seizure susceptibility continues up to at least age 200 days, (the oldest age studied).