Leprosy: a review on elimination, reducing the disease burden, and future research.
Leprosy: a review on elimination, reducing the disease burden, and future research.
复制标题
麻风病：关于消除、减轻疾病负担和未来研究的回顾。
DOI：
10.47276/lr.86.4.307
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发表时间：
2015
期刊：
影响因子：
0.6
通讯作者：
G. Marshman
中科院分区：
文献类型：
--
作者：
Casandra Chaptini;G. Marshman
麻风病是人类已知的最古老的疾病之一，是一种使人蒙受耻辱、可能致残的疾病。纵观历史，麻风病一直与恐惧、偏见和巨大的社会耻辱联系在一起。它仍然是传染病造成畸形和身体残疾的主要原因之一。世界卫生组织在控制麻风病方面取得了巨大进展，到2000年实现了“消灭麻风病”，其定义是将疾病流行率降至每10 000人1例以下。然而，现实情况是，真正的“消除”尚未实现。尽管进行了近30年的有效多药治疗，麻风病的流行和发病率自2005年以来一直处于稳定状态。此外，自2010年以来，2级残疾新发病例和儿童新发病例保持不变，这反映了早期麻风检测的失败，并表明传播显然仍在继续。本综述审查了消除疟疾的挑战，并提出了减少疾病负担的进一步措施，包括未来研究的可能性。
Leprosy, one of the oldest diseases known to man, is a stigmatising, potentially disabling disease. Throughout history, leprosy has been associated with fear, prejudice and immense social stigma. It remains one of the leading causes of deformity and physical disability from an infectious disease. Tremendous advances in leprosy control were made by the World Health Organization, and the 'elimination of leprosy', defined as a decrease of disease prevalence to less than 1 case per 10,000 population, was achieved by 2000. However, the reality is that true 'elimination' is yet to be achieved. Despite almost 30 years of effective multidrug treatment, the prevalence and incidence of leprosy have plateaued since 2005. Moreover, new cases with Grade 2 disability and new cases occurring in children remain unchanged since 2010, reflecting a failure in early leprosy detection, and indicating that transmission is clearly continuing. This review examines the challenges of elimination, and proposes further measures to reduce the disease burden, including future research possibilities.