ASSOCIATION BETWEEN SERUM INTERLEUKIN-6 AND SERUM 3,5,3'-TRIIODOTHYRONINE IN NONTHYROIDAL ILLNESS
ASSOCIATION BETWEEN SERUM INTERLEUKIN-6 AND SERUM 3,5,3'-TRIIODOTHYRONINE IN NONTHYROIDAL ILLNESS
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DOI：
10.1210/jc.77.6.1695
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发表时间：
1993-12-01
影响因子：
5.8
通讯作者：
WIERSINGA, WM
中科院分区：
文献类型：
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作者：
BOELEN, A;SCHIPHORST, MCP;WIERSINGA, WM
FFA、胆红素和羧甲基-丙基-呋喃丙酸的血清浓度升高，在慢性肾衰竭中与血清肌酐直接相关，均与疾病期间低T-3综合征的发病机制有关。细胞因子也可能参与病态甲状腺功能正常综合征。与白细胞介素-1（IL-1）和肿瘤坏死因子-α相反，IL-6通常在疾病期间在血清中可检测到，并且作为全身激素起作用。我们研究了在各种医疗条件下连续入院的血清T-3和IL-6之间的关系。将患者分为A组（T-3，≥ 1.30 nmol/L; T-4，≥ 75 nmol/L; n = 41）、B组（T-3，
Increased serum concentrations of FFA, bilirubin, and carboxylmethyl-propyl-furanpropionic acid, accumulating in chronic renal failure in direct relationship with serum creatinine, have all been impli cated in the pathogenesis of the low T-3 syndrome during illness. Cytokines may also be involved in the sick euthyroid syndrome. In contrast to interleukin-1 (IL-1) and tumor necrosis factor-alpha, IL-6 is usually detectable in serum during illness and acts as a systemic hormone. We studied the association between serum T-3 and IL-6 in consecutive hospital admissions with a wide variety of medical conditions. Patients were divided into group A (T-3, greater than or equal to 1.30 nmol/L; T-4, greater than or equal to 75 nmol/L; n = 41), group B (T-3,