Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy
Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy
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DOI：
10.1136/bjophthalmol-2017-311358
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发表时间：
2018-09-01
影响因子：
4.1
通讯作者：
Sadda, Srinivas
中科院分区：
文献类型：
--
作者：
Hirano, Takao;Kakihara, Shinji;Sadda, Srinivas
目的 探讨采用扩展视野成像 (EFI) 的宽视场正面扫源光学相干断层扫描血管造影 (SS-OCTA) 评估糖尿病视网膜病变 (DR) 视网膜脉管系统的可行性。 方法 本研究包括 27 名 DR 患者（年龄 65 +/- 10 岁；男性患者 18 名；女性患者 9 名）的 37 只眼睛。所有患者均接受全面的眼科检查，包括OCTA和荧光素血管造影（FA）。比较成像方法的可见视野、非灌注区域 (NPA) 的存在和范围、新血管 (NV) 的存在和数量、血管密度 (VD) 以及通过视觉模拟量表测量的患者舒适度。结果采用 EFI 的 SS-OCTA 比不采用 EFI 的 SS-OCTA 能够捕获更大的眼底区域（平均 1.80 +/- 0.18 倍）。与 FA 相比，SS-OCTA 结合 EFI 检测 NPA 和 NV 的灵敏度分别为 96% 和 79%，特异性分别为 100% 和 96%。 FA 和 EFI 的 SSOCTA 之间的 NPA 范围（61.2 +/- 45.8 vs 61.5 +/- 55.0 椎间盘面积，P=0.99）或 NV 数量（1.5 +/- 3.3 vs 0.9 +/- 1.8，P=0.68）没有显着差异。 EFI SS-OCTA 中的 VD 值显着低于未使用 EFI 采集的值（31.6%+/- 4.3% vs 34.2%+/- 4.3%，P
Aims To examine the feasibility of wide-field en face swept-source optical coherence tomography angiography (SS-OCTA) with extended field imaging (EFI) for evaluation of the retinal vasculature in diabetic retinopathy (DR).Methods This study included 37 eyes of 27 patients (age, 65 +/- 10 years; male patients, 18; female patients, 9) with DR. All patients underwent comprehensive ophthalmological examination, including OCTA and fluorescein angiography (FA). The imaging methods were compared for visible field of view, presence and extent of non-perfused areas (NPAs), presence and number of new blood vessels (NVs), vessel density (VD) and patient comfort level measured by Visual Analogue Scale.Results SS-OCTA with EFI allowed capture of larger areas (by 1.80 +/- 0.18 times on average) of the fundus than SS-OCTA without EFI. Compared with FA, the sensitivities of SS-OCTA with EFI for detection of NPAs and NVs were 96% and 79%, respectively, with specificities of 100% and 96%, respectively. There was no significant difference in extent of NPAs (61.2 +/- 45.8 vs 61.5 +/- 55.0 disc areas, P=0.99) or number of NVs (1.5 +/- 3.3 vs 0.9 +/- 1.8, P=0.68) between FA and SSOCTA with EFI. VD showed significantly lower values in EFI SS-OCTA than in those acquired without EFI (31.6%+/- 4.3% vs 34.2%+/- 4.3%, P