The blood-brain barrier in neurodegenerative disease: a rhetorical perspective.
The blood-brain barrier in neurodegenerative disease: a rhetorical perspective.
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DOI：
10.1111/j.1471-4159.2009.06319.x
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发表时间：
2009-10
影响因子：
4.7
通讯作者：
Monahan AJ
中科院分区：
文献类型：
--
作者：
Carvey PM;Hendey B;Monahan AJ
最近的研究表明，血脑屏障（BBB）的功能在正常生理条件下不是静止的，在神经退行性疾病中可能发生改变。关于中枢神经系统功能，特别是神经退行性疾病，普遍认为是神经中心性的，排除了中枢神经系统外因素的影响。这篇综述挑战了这一观点，并讨论了最近的报道，表明包括毒素和适应性免疫在内的外周因素的参与可能不仅在神经退行性疾病的发病机制中起作用，而且在疾病的进展中也起作用。这种观点的核心是神经炎症。一些研究表明，伴随神经退行性变的神经炎症改变通过改变运输系统、增强免疫细胞进入或影响血脑屏障作为信号接口的作用来影响血脑屏障或其功能。这种变化损害血脑屏障的正常稳态功能并影响神经活动。此外，最近的研究表明血脑屏障及其转运体的改变影响用于治疗神经退行性疾病的药物的进入。将血脑屏障损害和功能障碍纳入我们对神经退行性疾病的看法，导致其发病和进展中包括外周介质。此外，这种对血脑屏障的不断变化的看法为药物输送以及旨在恢复正常屏障功能的治疗策略提供了有趣的新治疗可能性。
Recent studies suggest that the function of the blood brain barrier (BBB) is not static under normal physiological conditions and is likely altered in neurodegenerative disease. Prevailing thinking about CNS function, and neurodegenerative disease in particular, is neurocentric excluding the impact of factors outside of the CNS. This review challenges this perspective and discusses recent reports suggesting the involvement of peripheral factors including toxins and elements of adaptive immunity that may not only play a role in pathogenesis, but also progression of neurodegenerative diseases. Central to this view is neuroinflammation. Several studies indicate that the neuroinflammatory changes that accompany neurodegeneration affect the BBB or its function by altering transport systems, enhancing immune cell entry, or influencing the BBB’s role as a signaling interface. Such changes impair the BBB’s normal homeostatic function and affect neural activity. Moreover, recent studies reveal that alterations in BBB and its transporters affect the entry of drugs used to treat neurodegenerative diseases. Incorporating BBB compromise and dysfunction into our view of neurodegenerative disease leads to inclusion of peripheral mediators in its pathogenesis and progression. In addition, this changing view of the BBB raises interesting new therapeutic possibilities for drug delivery as well as treatment strategies designed to reinstate normal barrier function.
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影响因子：
15.9
作者：
Brochard, Vanessa;Combadiere, Behazine;Hunot, Stephane
通讯作者：
Hunot, Stephane
影响因子：
3.7
作者：
Benner EJ;Banerjee R;Reynolds AD;Sherman S;Pisarev VM;Tsiperson V;Nemachek C;Ciborowski P;Przedborski S;Mosley RL;Gendelman HE
通讯作者：
Gendelman HE
DOI：
10.1093/gerona/55.12.b601
发表时间：
2000-12-01
影响因子：
5.1
作者：
Banks, WA;Farr, SA;Morley, JE
通讯作者：
Morley, JE
影响因子：
2.9
作者：
Banks, William A.
通讯作者：
Banks, William A.
影响因子：
3.2
作者：
Bendayan, Reina;Ronaldson, Patrick T.;Bendayan, Moise
通讯作者：
Bendayan, Moise