Vitamin D Deficiency as a Strong Predictor of Asthma in Children
Vitamin D Deficiency as a Strong Predictor of Asthma in Children
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DOI：
10.1159/000323941
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Hamid, Qutayba
中科院分区：
文献类型：
--
作者：
Bener, Abdulbari;Ehlayel, Mohammad S.;Hamid, Qutayba
背景：流行病学研究表明，生命早期维生素D缺乏与晚年哮喘的发生之间存在联系。目的：本研究的目的是测定哮喘儿童的血清维生素D水平，并与健康非哮喘对照组进行比较。研究方法：从2009年10月至2010年7月，从哈马德总医院的儿科过敏免疫学诊所和卡塔尔的初级卫生保健诊所招募了哮喘（n = 483）和健康对照（n = 483）儿童。所有儿童均在16岁以下，哮喘由医生诊断。所有儿童的父母都完成了广泛的问卷调查，记录了人口统计学，儿童的喂养习惯和维生素D摄入量。进行血清维生素D（25-羟基维生素D）、钙、磷、碱性磷酸酶、镁、肌酐和甲状旁腺激素测定。血清中维生素D含量低于20 ng/ml的受试者被视为缺乏。结果如下：与非哮喘儿童相比，哮喘儿童的血清维生素D水平显著降低（p < 0.001）; 68.1%的哮喘患者维生素D缺乏。与健康对照组相比，哮喘儿童的中度（41.8%对25.1%）和重度（26.3%对11.0%）维生素D缺乏程度显著更高（p
Background: Epidemiological studies suggest a link between vitamin D deficiency in early life and development of asthma in later life. Aim:The aim of this study was to measure serum vitamin D levels in asthmatic children and to compare these to healthy non-asthmatic controls. Methods: Asthmatic (n = 483) and healthy control (n = 483) children were recruited from the Pediatric Allergy-Immunology Clinics of Hamad General Hospital and the Primary Health Care Clinics in Qatar from October 2009 to July 2010. All children were below 16 years of age and asthma was diagnosed by a physician. Parents of all children completed extensive questionnaires documenting demographics, child's feeding practice and vitamin D intake. Serum vitamin D (25-hydroxyvitamin D), calcium, phosphorus, alkaline phosphatase, magnesium, creatinine and parathyroid hormone assays were performed. Subjects with serum containing less than 20 ng/ml vitamin D were deemed deficient. Results: Asthmatic children had significantly reduced serum vitamin D levels compared to non-asthmatic children (p < 0.001); 68.1% of all asthmatics were vitamin D deficient. Asthmatic children had significantly higher degrees of moderate (41.8 vs. 25.1%) and severe (26.3 vs. 11.0%) vitamin D deficiency compared to healthy controls (p