Benzoylphenylurea sulfur analogues with potent antitumor activity
Benzoylphenylurea sulfur analogues with potent antitumor activity
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DOI：
10.1021/jm051261s
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发表时间：
2006-04-06
影响因子：
7.3
通讯作者：
Khan, SR
中科院分区：
文献类型：
--
作者：
Hallur, G;Jimeno, A;Khan, SR
A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to10-fold increased potency, when compared to I (NSC-639829), against cancer cell lines. 6n was more effective than I in causing apoptosis of MCF-7 cells. When compared to other drugs with a similar mechanism of action, 6n retained significant ability to inhibit tubulin assembly, with an IC50 of 2.1 mu M.
