Stress-induced elevation of testosterone concentration in high ranking baboons: role of catecholamines.
Stress-induced elevation of testosterone concentration in high ranking baboons: role of catecholamines.
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应激引起的高级狒狒睾酮浓度升高：儿茶酚胺的作用。
DOI：
10.1210/endo-118-4-1630
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发表时间：
1986
期刊：
影响因子：
4.8
通讯作者：
R. Sapolsky
中科院分区：
文献类型：
--
作者：
R. Sapolsky
在一项对生活在肯尼亚保护区的野生橄榄狒狒的持续研究中，研究了睾丸轴对快速捕获和固定的急性压力的反应。应激抑制LH和睾酮（T）浓度;先前的研究表明，这是由于应激诱导的阿片类药物和糖皮质激素释放，分别抑制LH释放和睾丸对LH的敏感性。这种现象有相当大的个体差异，这与个体男性的社会地位有关。高排名的男性（生殖标准）不太容易受到压力对T浓度的抑制作用，事实上，在应激后的第一个小时内，T浓度呈一过性增加。相反，下属的T浓度迅速持续下降。尽管两组中LH浓度相似，但T曲线存在差异，表明高等级雄性动物T浓度一过性升高的外周机制。这种独特的模式部分是由于高级雄性睾丸对糖皮质激素抑制作用的敏感性较低。本报告提出了另一个机制，以解决这种与职级有关的差异。氯异松达明（一种交感神经节阻滞剂，可减弱应激诱导的肾上腺素和去甲肾上腺素释放）给药未能改变低等级雄性动物或高等级雄性动物LH或T曲线的任何方面。然而，其完全消除了这些雄性动物中T浓度的一过性升高。这表明，交感神经的儿茶酚胺，在压力和周围，直接或许可地导致T浓度增加的作用释放。这可能是通过增加通过睾丸的血流量和/或通过直接刺激T释放的儿茶酚胺。这种睾丸的交感神经调节的限制，以高排名的男性表明，无论是增强交感神经紧张在这些动物的压力（相对于下属）或增强靶组织的敏感性，儿茶酚胺。
In an ongoing study of wild olive baboons living in a protected reserve in Kenya, the response of the testicular axis to the acute stress of rapid capture and immobilization was studied. The stress suppressed LH and testosterone (T) concentrations; previous work showed this to be due to stress-induced release of opiates and glucocorticoids, acting to inhibit LH release and testicular sensitivity to LH, respectively. There was considerable individual variation in this phenomenon, which was related to the social status of individual males. High ranking males (by reproductive criteria) were less vulnerable to the suppressive effects of stress on T concentrations and, in fact, showed transient increases in T concentrations during the first poststress hour. T concentrations in subordinates, in contrast, declined promptly and continuously. This difference in T profiles occurred despite similar suppressions of LH concentrations in both groups, suggesting a peripheral mechanism for the transient elevation of T concentrations in high ranking males. Part of this distinctive pattern had been shown to be due to the lesser sensitivity of the testes of high ranking males to the suppressive effects of glucocorticoids. The present report suggests an additional mechanism accounting for this rank-related difference. Administration of chlorisondamine, a sympathetic ganglionic blocker which attenuates stress-induced release of epinephrine and norepinephrine, failed to alter any aspect of LH or T profiles in low ranking males or LH profiles in high ranking males. However, it completely eliminated the transient rise in T concentrations in these males. This suggests that sympathetic catecholamines, released during stress and acting peripherally, directly, or permissively lead to increased T concentrations. This could be via increased blood flow through the testes and/or through direct stimulation of T release by catecholamines. The limitation of this sympathetic regulation of the testes to high ranking males suggests either enhanced sympathetic tone during stress in these animals (relative to subordinates) or enhanced target tissue sensitivity to catecholamines.
体外人胎儿下丘脑释放促性腺激素释放激素的内源性阿片类药物调节。
DOI：
10.1210/jcem-57-5-881
发表时间：
1983
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Rasmussen,DD;Liu,JH;Wolf,PL;Yen,SS
通讯作者：
Yen,SS