A simple deprotection of triflate esters of phenol derivatives
A simple deprotection of triflate esters of phenol derivatives
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DOI：
10.1016/j.tetlet.2004.06.104
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发表时间：
2004-08-09
影响因子：
1.8
通讯作者：
Nishiyama, S
中科院分区：
文献类型：
--
作者：
Ohgiya, T;Nishiyama, S
用Et4NOH有效地将芳基三氟酸酯转化为相应的酚类。与其它裂解反应相比，反应条件下硝基、酮基、卤素基、酰胺基、磺胺基等官能团完好无损。这种温和去除三氟甲烷磺酰基的方法将成为一种新的酚类保护基团。(C) 2004 Elsevier Ltd.版权所有。
Efficient conversion of aryl triflates into the corresponding phenols has been accomplished with Et4NOH. In contrast to other cleavage reactions, such functional groups as nitro, ketone, halogen, amide and sulfonamide groups were intact under the reaction conditions. This mild removal of the trifluoromethanesulfonyl group would serve a new protecting group of phenols. (C) 2004 Elsevier Ltd. All rights reserved.