Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine
Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine
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DOI：
10.1016/j.drugalcdep.2017.07.041
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发表时间：
2017-11-01
影响因子：
4.2
通讯作者：
Gatch, Michael B.
中科院分区：
文献类型：
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作者：
Dolan, Sean B.;Forster, Michael J.;Gatch, Michael B.
尽管各理事机构加强了监管，但新型精神活性物质在全球毒品文化中仍保持着突出的作用。新的化合物继续在市场上出现，通常是以“摇头丸”或“莫莉”的形式代替MDMA，其速度远远快于对其进行适当表征的速度。目前的研究旨在研究三种在药物市场上日益流行的致敏化合物的辨别刺激和运动效应：5-（2-氨基丙基）苯并呋喃（5-APB），6-（2-氨基丙基）-2，3-二氢苯并呋喃（6-APDB）和4-氟苯丙胺（4-FA）。使用Swiss-Webster小鼠在运动活动的旷场试验中评估运动刺激作用。在训练用于区分可卡因、甲基苯丙胺、DOM或MDMA与溶剂的Sprague-Dawley大鼠中评估了辨别刺激效应。苯并呋喃化合物产生自发刺激，而4-FA抑制自发活动。苯并呋喃取代MDMA的歧视性刺激作用，但仅部分或根本没有甲基苯丙胺，可卡因和DOM，而4-FA完全取代MDMA，甲基苯丙胺和可卡因，但没有DOM。这些结果表明，苯并呋喃类药物的滥用模式可能与MDMA类似，而4-FA可能被精神兴奋剂和MDMA替代。
Novel psychoactive substances have maintained a prominent role in the global drug culture, despite increased regulation by governing bodies. Novel compounds continue to become available on the market, ofteh in "Ecstasy" or "Molly" formulations in lieu of MDMA, at a much faster rate than they can be properly characterized. The current study aimed to investigate the discriminative stimulus and locomotor effects of three putatively entactogenic compounds that have become increasingly prevalent on the drug market: 5-(2-aminopropyl)benzofuran (5-APB), 6-(2-aminopropryl)-2,3-dihydrobenzofuran (6-APDB), and 4-fluoroamphetamine (4-FA). Locomotor stimulant effects were assessed in an open-field assay for locomotor activity using Swiss-Webster mice. Discriminative stimulus effects were assessed in Sprague-Dawley rats trained to discriminate either cocaine, methamphetamine, DOM, or MDMA from vehicle. The benzofuran compounds produced locomotor stimulation whereas 4-FA depressed locomotor activity. The benzofurans substituted for the discriminative stimulus effects of MDMA, but only partially or not at all for methamphetamine, cocaine, and DOM, whereas 4-FA fully substituted for MDMA, methamphetamine and cocaine, but not DOM. These results indicate an MDMA-like pattern of abuse might be expected for the benzofurans, whereas 4-FA may be substituted for psychostimulants and MDMA.