Increased early life stress and depressive symptoms in patients with comorbid substance abuse and schizophrenia.
Increased early life stress and depressive symptoms in patients with comorbid substance abuse and schizophrenia.
复制标题
药物滥用和精神分裂症共存患者的早期生活压力和抑郁症状增加。
DOI：
10.1093/oxfordjournals.schbul.a006933
复制
发表时间：
2002
影响因子：
6.6
通讯作者：
Miller,AndrewH
中科院分区：
文献类型：
--
作者：
Scheller-Gilkey,Geraldine;Thomas,ShannonM;Woolwine,BobbiJ;Miller,AndrewH
早期的不良事件与药物滥用和抑郁症的发生率增加有关。为探讨精神分裂症患者早期不良事件与共病物质滥用的关系，对40例精神分裂症患者的早期生活应激、抑郁症状、阳性和阴性症状、焦虑和认知功能进行了测量。与没有药物滥用史的患者相比，有药物滥用史的精神分裂症患者的早期生活创伤发生率显著更高，修订的汉密尔顿抑郁评定量表和精神病学流行病学研究访谈生活事件量表的得分也显著更高。两组之间在阳性或阴性症状、焦虑或认知功能方面没有差异。这些结果强调了精神分裂症患者早期生活压力和情感症状的重要性，以及它们与物质滥用障碍的潜在关系。
Early adverse events have been associated with increased rates of substance abuse and depression. To investigate the association between early adverse events and comorbid substance abuse in schizophrenia patients, early life stress, depressive symptoms, positive and negative symptoms, anxiety, and cognitive function were measured in an age-, sex-, and racematched sample of 40 schizophrenia patients with and without comorbid substance abuse. Compared to patients without substance abuse, patients with schizophrenia and a history of substance abuse had a significantly higher incidence of early life trauma, as well as significantly higher scores on the Modified Hamilton Rating Scale for Depression and the Psychiatric Epidemiology Research Interview Life Events Scale. No differences between groups were found in positive or negative symptoms, anxiety, or cognitive function. The results emphasize the importance of early life stress and affective symptoms and their potential relationship to substance abuse disorders in schizophrenia patients.