The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions.
The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions.
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DOI：
10.1038/sj.bjc.6604305
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发表时间：
2008-04-22
影响因子：
8.8
通讯作者：
Easton, D. F.
中科院分区：
文献类型：
--
作者：
Antoniou, A. C.;Cunningham, A. P.;Peto, J.;Evans, D. G.;Lalloo, F.;Narod, S. A.;Risch, H. A.;Eyfjord, J. E.;Hopper, J. L.;Southey, M. C.;Olsson, H.;Johannsson, O.;Borg, A.;Passini, B.;Radice, P.;Manoukian, S.;Eccles, D. M.;Tang, N.;Olah, E.;Anton-Culver, H.;Warner, E.;Lubinski, J.;Gronwald, J.;Gorski, B.;Tryggvadottir, L.;Syrjakoski, K.;Kallioniemi, O-P;Eerola, H.;Nevanlinna, H.;Pharoah, P. D. P.;Easton, D. F.
多个基因位点赋予乳腺癌和卵巢癌的易感性。我们以前开发了一个模型（BOADICEA），根据该模型，乳腺癌的易感性可以通过BRCA 1和BRCA 2的突变以及许多基因（多基因成分）的联合倍增效应来解释。我们现在已经更新了BOADICEA，使用了来自两项英国基于人群的乳腺癌研究的额外家族数据，以及来自22项基于人群的乳腺癌或卵巢癌研究确定的BRCA 1和BRCA 2携带者的家族数据。合并数据集包括2785个家庭（301个BRCA 1阳性和236个BRCA 2阳性）。使用局部加权回归技术平滑发生率，以避免相邻区间之间的较大变化。实施了对癌症风险的出生队列效应，即根据日历期间特定的发病率假设每个人患癌症。拟合模型预测，携带者的平均乳腺癌风险在最近的出生队列中增加。例如，BRCA 1携带者中70岁的平均累积乳腺癌风险在1920-1929年出生的女性中为50%，在1950年以后出生的女性中为58%。该模型被进一步扩展，以考虑男性乳腺癌、前列腺癌和胰腺癌的风险，并考虑到多种癌症的风险。BOADICEA可用于预测具有任何家族史的个体的携带者概率和癌症风险，并已在用户友好的基于网络的程序中实施（http：//www.srl.cam.ac.uk/genepi/boadicea/boadicea_home.html）。
Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families (301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920–1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in a user-friendly Web-based program (http://www.srl.cam.ac.uk/genepi/boadicea/boadicea_home.html).
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影响因子：
9.8
作者：
Edwards, SM;Kote-Jarai, Z;Eeles, RA
通讯作者：
Eeles, RA
DOI：
10.1093/jnci/94.18.1365
发表时间：
2002-09-18
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Brose, MS;Rebbeck, TR;Weber, BL
通讯作者：
Weber, BL
影响因子：
6.8
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
BRCA1和BRCA2突变使用Boadicea和Brcapro模型以及高危法国加拿大家庭中的渗透率估计。
影响因子：
7.4
作者：
Antoniou, AC;Durocher, F;Smith, P;Simard, J;Easton, DF
通讯作者：
Easton, DF
影响因子：
11.5
作者：
Kirchhoff, T;Kauff, ND;Offit, K
通讯作者：
Offit, K