An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients.
An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients.
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DOI：
10.1111/ajt.16460
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Northwell Health COVID-19 Research Consortium
中科院分区：
文献类型：
--
作者：
Nair V;Jandovitz N;Hirsch JS;Abate M;Satapathy SK;Roth N;Miyara SJ;Guevara S;Kressel AM;Xiang A;Wu G;Butensky SD;Lin D;Williams S;Bhaskaran MC;Majure DT;Grodstein E;Lau L;Nair G;Fahmy AE;Winnick A;Breslin N;Berlinrut I;Molmenti C;Becker LB;Malhotra P;Gautam-Goyal P;Lima B;Maybaum S;Shah SK;Takegawa R;Hayashida K;Shinozaki K;Teperman LW;Molmenti EP;Northwell Health COVID-19 Research Consortium
我们比较了免疫抑制的实体器官移植(SOT)患者和单纯移植的人群中使用新冠肺炎的结果。分析了2020年3月1日至2020年4月27日期间新冠肺炎的10356例成人住院病例。收集了有关人口统计学、基线临床条件、药物、免疫抑制和新冠肺炎病程的数据。主要结果是合并死亡或机械通气。我们使用双变量和多变量回归模型评估了主要结果和预后变量之间的关系。我们还将SOT患者的主要终点与年龄、性别和共病匹配的对照组进行了比较。双变量分析发现，移植状态、年龄、性别、种族/民族、体重指数、糖尿病、高血压、心血管疾病、慢性阻塞性肺疾病和肾小球滤过率60毫升/分钟/1.73平方米是合并死亡或机械通气的显著预测因素。经多因素Logistic回归分析，SOT状态有统计学意义(优势比[OR]1.29；95%可信区间0.99~1.69，P=0.06)。与年龄、性别和共病相匹配的对照组相比，SOT患者死亡或机械通气的综合风险更高(OR 1.34；95%CI 1.03-1.74，p=0.027)。
We compared the outcome of COVID-19 in immunosuppressed solid organ transplant (SOT) patients to a transplant naïve population. In total, 10 356 adult hospital admissions for COVID-19 from March 1, 2020 to April 27, 2020 were analyzed. Data were collected on demographics, baseline clinical conditions, medications, immunosuppression, and COVID-19 course. Primary outcome was combined death or mechanical ventilation. We assessed the association between primary outcome and prognostic variables using bivariate and multivariate regression models. We also compared the primary endpoint in SOT patients to an age, gender, and comorbidity-matched control group. Bivariate analysis found transplant status, age, gender, race/ethnicity, body mass index, diabetes, hypertension, cardiovascular disease, COPD, and GFR <60 mL/min/1.73 m2 to be significant predictors of combined death or mechanical ventilation. After multivariate logistic regression analysis, SOT status had a trend toward significance (odds ratio [OR] 1.29; 95% CI 0.99–1.69, p = .06). Compared to an age, gender, and comorbidity-matched control group, SOT patients had a higher combined risk of death or mechanical ventilation (OR 1.34; 95% CI 1.03–1.74, p = .027).
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影响因子：
39
作者：
Wu, Chaomin;Chen, Xiaoyan;Song, Yuanlin
通讯作者：
Song, Yuanlin
影响因子：
8.8
作者：
Chaudhry, Zohra S.;Williams, Jonathan D.;Alangaden, George J.
通讯作者：
Alangaden, George J.
DOI：
10.1001/jama.2020.6775
发表时间：
2020-01-01
期刊：
JAMA, Journal of the American Medical Association
影响因子：
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作者：
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通讯作者：
,
DOI：
10.1111/ajt.15929
发表时间：
2020-07
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
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作者：
通讯作者：
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影响因子：
8.8
作者：
Cravedi, Paolo;Mothi, Suraj S.;Riella, Leonardo, V
通讯作者：
Riella, Leonardo, V