Synthesis and antitumor activity of icogenin and its analogue.
Synthesis and antitumor activity of icogenin and its analogue.
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DOI：
10.1016/j.bmcl.2006.01.074
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发表时间：
2006-05
影响因子：
2.7
通讯作者：
Shu-jie Hou;P. Xu;Liang Zhou;Dequan Yu;P. Lei
中科院分区：
文献类型：
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作者：
Shu-jie Hou;P. Xu;Liang Zhou;Dequan Yu;P. Lei
天然皂苷麦角苷元，即25(S)-22-O-甲基-furost-5-en-3β,26-dio-3-O-α-l-吡喃鼠李糖基-(1→2)-[β-d-吡喃葡萄糖基-(1→3)]-β-d-吡喃葡萄糖苷，及其类似物之一，首先分别通过直线策略和收敛方法合成了25(S)-22-O-methyl-furost-5-en-3β,26-dio-3-O-α-l-吡喃鼠李糖基-(1→2)-[β-d-吡喃葡萄糖基-(1→3)]-α-d-吡喃葡萄糖苷。据观察，茄子配基及其类似物在体外表现出有效的抗肿瘤活性。
Natural saponin icogenin, namely 25(S)-22-O-methyl-furost-5-en-3β,26-dio-3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-glucopyranoside, and one of its analogues, 25(S)-22-O-methyl-furost-5-en-3β,26-dio-3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-α-d-glucopyranoside, were first synthesized via line strategy and convergent approach, respectively. It was observed that icogenin and its analogue show potent antitumor activity in vitro.