Oseltamivir enhances hippocampal network synchronization
Oseltamivir enhances hippocampal network synchronization
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DOI：
10.1254/jphs.sc0070467
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发表时间：
2008-04-01
影响因子：
3.5
通讯作者：
Ikegaya, Yuji
中科院分区：
文献类型：
--
作者：
Usami, Atsushi;Sasaki, Takuya;Ikegaya, Yuji
奥司他韦是一种广泛使用的抗流感药物，可抑制病毒神经氨酸酶。这种酶的哺乳动物同源物在大脑中表达，但奥司他韦对中枢神经元的影响在很大程度上是未知的。离体膜片钳记录显示，奥司他韦增强海马CA3区锥体细胞之间的锋电位同步。延时多神经元钙成像显示，奥司他韦及其活性代谢产物诱发同步群体爆发，几乎招募了网络中的所有神经元。这种独特的，迄今未知的，事件减弱了毒蕈碱受体拮抗剂。因此，奥司他韦是研究神经回路运作新方面的有用工具http://dx.doi.org/10.1254/jphs.SC0070467
Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation.Supplementary Fig. and movie: available only at http://dx.doi.org/10.1254/jphs.SC0070467