Cardiovascular, Metabolic, and Coronary Dysfunction in High-Fat-Fed Obesity-Resistant/Prone Rats
Cardiovascular, Metabolic, and Coronary Dysfunction in High-Fat-Fed Obesity-Resistant/Prone Rats
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DOI：
10.1002/oby.21009
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发表时间：
2015-03-01
期刊：
影响因子：
6.9
通讯作者：
Oltman, Christine L.
中科院分区：
文献类型：
--
作者：
Dake, Brian L.;Oltman, Christine L.
肥胖是一种全球流行病，导致包括糖尿病和心血管疾病在内的多种合并症。肥胖倾向大鼠（OP）的遗传背景易导致生理、代谢、和微血管功能障碍，这是加剧了饮食高饱和fats.MethodsMale OP和肥胖抵抗（OR）大鼠喂养的饮食含有10%（chow）或45%千卡脂肪（HF）结果8周时OP组大鼠体重均大于OR组。与采用类似饮食的OR大鼠相比，OP大鼠的血压升高，HF饮食进一步升高。与体重和血压相比，OR和OP大鼠的葡萄糖清除率相似，而HF饮食的两种模型的葡萄糖清除率均受损。与OR大鼠相比，OP大鼠对乙酰胆碱的松弛在8周时减弱，并且在整个研究期间保持减少。需要一个较长的时间来观察HF喂养的OR rats.ConclusionsWhen相比，OR大鼠血管功能障碍，OP大鼠容易发展不仅更大的肥胖，但也高血压和血管功能障碍的正常饮食，这是进一步增强与HF饮食。
ObjectiveObesity is a global epidemic leading to several comorbidities including diabetes and cardiovascular disease. The hypothesis that the genetic background of the obesity-prone rat (OP) predisposes to physiologic, metabolic, and microvascular dysfunction which is exacerbated by a diet high in saturated fats was tested.MethodsMale OP and obesity-resistant (OR) rats were fed either a diet containing 10% (chow) or 45% kcal fat (HF) for 42 weeks.ResultsWeight of OP rats was greater than OR rats by 8 weeks on both diets. Blood pressure was increased in OP rats on chow and further augmented by HF diet compared to OR rats on similar diets. In contrast to weight and blood pressure, glucose clearance was similar in OR and OP rats on chow and impaired in both models on HF diet. Relaxation to acetylcholine was attenuated in OP rats compared to OR rats by 8 weeks and remained reduced throughout the study. A longer period of time was required to observe vascular dysfunction in HF-fed OR rats.ConclusionsWhen compared to OR rats, OP rats are prone to develop not only greater obesity but also hypertension and vascular dysfunction on a normal diet which is further augmented with HF diet.