Limitation of cigarette consumption by CYP2A6*4, *7 and *9 polymorphisms
Limitation of cigarette consumption by CYP2A6*4, *7 and *9 polymorphisms
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DOI：
10.1183/09031936.06.00056305
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发表时间：
2006-02-01
影响因子：
24.3
通讯作者：
Ishizaka, A
中科院分区：
文献类型：
--
作者：
Minematsu, N;Nakamura, H;Ishizaka, A
主要尼古丁氧化酶的缺陷--全基因缺失-的全基因缺失然而，在亚洲人群中常见的两个主要功能多态--CYP2A6*7和*9对吸烟习惯的影响尚未见报道。本研究调查了200名日本人吸烟习惯与*4、*7和*9之间的关系，其中*1(野生型)、*4、*7和*9等位基因频率分别为52、17、11和20%。当同时考虑这三种多态时，野生型、杂合型、突变纯合型和复合杂合子的比例分别为26.0%、52.5%和21.5%。纯合子突变个体和复合杂合子个体(n=43)比杂合子个体(n=105)和纯合子野生型个体(n=52)每天吸烟更少。携带*7/*7、*9/*9或*71*9基因的吸烟者较携带*1/*1基因的吸烟者每日吸烟量更低。结论：大约3/4的日本吸烟者检测到CYP2A6基因*4、*7和*9的多态，他们的日常吸烟量受这些功能多态的遗传调控。
The whole gene deletion CYP2A6*4, the defect of the main nicotine oxidase, contributes to limiting lifelong and daily cigarette consumption. However, the effects on smoking habits of CYP2A6*7 and *9, two major functional polymorphisms common in Asian populations, have not been reported.The present study examined the relationship between polymorphisms *4, *7 and *9 with the smoking habits of 200 Japanese smokers who visited the Keio University Hospital (Tokyo, Japan).The allele frequencies of *1 (wild type), *4, *7 and *9 were 52, 17, 11 and 20%, respectively. When the three polymorphisms were considered simultaneously, the percentages of homozygous wild type, heterozygote, and homozygous mutants and compound heterozygotes were 26.0, 52.5 and 21.5%, respectively. Homozygous mutants and compound heterozygotes (n=43) smoked fewer cigarettes daily than heterozygotes (n=105) and homozygous wild-type individuals (n=52). Smokers with *7/*7, *9/*9 or *71*9 had lower daily cigarette consumption than smokers with *1/*1.In conclusion, polymorphisms *4, *7 and *9 of CYP2A6 were detected in approximately three out of four Japanese smokers, and their daily cigarette consumption was genetically modulated by these functional polymorphisms.