Operant behavior of rats exposed to lead before or after weaning.
Operant behavior of rats exposed to lead before or after weaning.
复制标题
断奶前后暴露于铅的大鼠的操作行为。
DOI：
10.1016/0041-008x(82)90027-8
复制
发表时间：
1982
影响因子：
3.8
通讯作者：
Weiss,B
中科院分区：
文献类型：
--
作者：
Angell,NF;Weiss,B
大鼠在断奶前或断奶后暴露于铅（Pb）。对于断奶前的暴露，哺乳母鼠接受0.2%的醋酸铅（1090 ppm铅）的饮用水。断奶后处理的后代消耗相同的浓度。自来水作为对照流体。实验分为自来水-自来水、铅-自来水、自来水-铅、铅-铅4个实验组，每组10只。出生后第58天开始进行操作行为训练。动物进行了多次强化计划的食物介绍，包括固定的时间间隔，fixedratio，和超时组件。实验阶段4至11（出生后第72至79天）的统计分析显示，断奶后暴露显着延长了间隔和比率时间表上连续反应之间的中位间隔（反应间时间）。断奶前暴露单独倾向于产生缩短中位反应时间。其他性能指标和随后的比值大小变化显示处理组之间的关系相似但无显著差异。未检测到显著的组织病理学。脑和血铅浓度与治疗方案一致。
Rats were exposed to lead (Pb) before or after weaning. For preweaning exposures, nursing dams received 0.2% Pb acetate(1090 ppm Pb) in drinking water. Offspring treated after weaning consumed the same concentration. Tapwater served as the control fluid. Pre-post treatments were distributed among four experimental groups of 10 rats each: tap water-tap water, Pb-tap water, tap water-Pb, Pb-Pb. Operant behavior training began on Postnatal Day 58. Animals performed on a multiple reinforcement schedule of food presentation consisting of fixed-interval, fixedratio, and time out components. Statistical analyses of experimental sessions 4 to 11 (Postnatal Days 72 to 79) revealed that postweaning exposure significantly lengthened the median interval (interresponse time) between consecutive responses on both the interval and ratio schedules. Preweaning exposure alone tended to produce a shortening of the median interresponse time. Other performance indices and subsequent variations of ratio size showed similar but not significantly different relationships among the treatment groups. No significant histopathology was detected. Brain and blood Pb concentrations were consistent with the treatment protocol.