Differential Regulation of the Immune Response in the Spleen and Liver of Mice Infected with Leishmania donovani.
Differential Regulation of the Immune Response in the Spleen and Liver of Mice Infected with Leishmania donovani.
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DOI：
10.1155/2012/639304
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发表时间：
2012
影响因子：
2.2
通讯作者：
Stäger S
中科院分区：
文献类型：
--
作者：
Bankoti R;Stäger S
对病原体的免疫需要产生有效的先天和适应性免疫反应。多诺瓦利什曼原虫避开了这些宿主防御机制，在宿主体内存活并持续存在。更好地理解和确定多诺瓦氏杆菌的生存机制对于开发专门针对寄生虫的新型治疗干预措施至关重要。本文将重点介绍寄生虫利用其持久性的一些机制，并讨论如何调节免疫反应。
Immunity to pathogens requires generation of effective innate and adaptive immune responses. Leishmania donovani evades these host defense mechanisms to survive and persist in the host. A better understanding and identification of mechanisms that L. donovani employs for its survival is critical for developing novel therapeutic interventions that specifically target the parasite. This paper will highlight some of the mechanisms that the parasite utilizes for its persistence and also discuss how the immune response is regulated.