Free-breathing contrast-enhanced multiphase MRI of the liver using a combination of compressed sensing, parallel imaging, and golden-angle radial sampling.
Free-breathing contrast-enhanced multiphase MRI of the liver using a combination of compressed sensing, parallel imaging, and golden-angle radial sampling.
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DOI：
10.1097/rli.0b013e318271869c
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发表时间：
2013-01
影响因子：
6.7
通讯作者：
Otazo R
中科院分区：
文献类型：
--
作者：
Chandarana H;Feng L;Block TK;Rosenkrantz AB;Lim RP;Babb JS;Sodickson DK;Otazo R
本研究的目的是开发一种结合压缩传感、并行成像和径向k空间采样的自由呼吸对比剂增强多相肝脏磁共振成像(MRI)的新方法，并通过与健康受试者屏气笛卡尔T1加权(常规)增强后采集的图像质量比较来证明该方法的可行性。这项符合《健康保险可携带性和责任法案》的前瞻性研究获得了机构审查委员会的批准。8名受试者分别接受了3次对比增强脂肪饱和T1加权梯度回波MRI检查，检查参数与成像参数相匹配：常规屏气检查采用笛卡尔k空间采样体积内插屏气检查(BH-VIBE)，自由呼吸采集采用交错角度平分和连续黄金角径向采样方案。使用压缩传感和并行成像(交错角径向稀疏平行[IARASP]和黄金角径向稀疏平行[GRAP])相结合的方法重建每100条连续辐条的交错角度平分和黄金角度数据，以生成多个增强后相位。动脉和静脉期的BH-VIBE、IARASP和GRAP重建由2位放射科医生以盲法进行评估。读者对增强质量(QE)、整体图像质量(IQ)和其他图像质量参数进行了5分制的独立评估，最高分表示最理想的检查。采用混合模型方差分析比较图像质量的各项指标。BH-VIBE和GRAPH图像的QE和IQ值均显著高于IARASP(P<；0.05)。BH-VIBE和GRAPH在动脉和静脉期的QE差异无统计学意义(P>；0.05)。尽管GRASP在动脉(3.9vs4.8；P<；0.0001)和静脉期(4.2vs4.8；P=0.005)的智商得分低于BH-VIBE，但所有参与者的智商都在3分或以上，这与可接受或更好的诊断图像质量是一致的。使用压缩传感、平行成像和黄金角径向采样的组合，可以在自由呼吸期间进行具有诊断质量的对比增强多期肝脏MRI。
The objectives of this study were to develop a new method for free-breathing contrast-enhanced multiphase liver magnetic resonance imaging (MRI) using a combination of compressed sensing, parallel imaging, and radial k-space sampling and to demonstrate the feasibility of this method by performing image quality comparison with breath-hold cartesian T1-weighted (conventional) postcontrast acquisitions in healthy participants. This Health Insurance Portability and Accountability Act–compliant prospective study received approval from the institutional review board. Eight participants underwent 3 separate contrast-enhanced fat-saturated T1-weighted gradient-echo MRI examinations with matching imaging parameters: conventional breath-hold examination with cartesian k-space sampling volumetric interpolate breath hold examination (BH-VIBE) and free-breathing acquisitions with interleaved angle-bisection and continuous golden-angle radial sampling schemes. Interleaved angle-bisection and golden-angle data from each 100 consecutive spokes were reconstructed using a combination of compressed sensing and parallel imaging (interleaved-angle radial sparse parallel [IARASP] and golden-angle radial sparse parallel [GRASP]) to generate multiple postcontrast phases. Arterial- and venous-phase BH-VIBE, IARASP, and GRASP reconstructions were evaluated by 2 radiologists in a blinded fashion. The readers independently assessed quality of enhancement (QE), overall image quality (IQ), and other parameters of image quality on a 5-point scale, with the highest score indicating the most desirable examination. Mixed model analysis of variance was used to compare each measure of image quality. Images of BH-VIBE and GRASP had significantly higher QE and IQ values compared with IARASP for both phases (P < 0.05). The differences in QE between BH-VIBE and GRASP for the arterial and venous phases were not significant (P > 0.05). Although GRASP had lower IQ score compared with BH-VIBE for the arterial (3.9 vs 4.8; P < 0.0001) and venous (4.2 vs 4.8; P = 0.005) phases, GRASP received IQ scores of 3 or more in all participants, which was consistent with acceptable or better diagnostic image quality. Contrast-enhanced multiphase liver MRI of diagnostic quality can be performed during free breathing using a combination of compressed sensing, parallel imaging, and golden-angle radial sampling.