Constraining OCT with Knowledge of Device Design Enables High Accuracy Hemodynamic Assessment of Endovascular Implants
Constraining OCT with Knowledge of Device Design Enables High Accuracy Hemodynamic Assessment of Endovascular Implants
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DOI：
10.1371/journal.pone.0149178
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发表时间：
2016-02-23
期刊：
影响因子：
3.7
通讯作者：
Edelman, Elazer R.
中科院分区：
文献类型：
--
作者：
O'Brien, Caroline C.;Kolandaivelu, Kumaran;Edelman, Elazer R.
背景血管内图像的叠加横截面允许血管内植入物的三维呈现，但是引入了限制装置放置和血流动力学微环境的表征的帧间不确定性。在猪冠状动脉支架模型中，我们展示了增强OCT重建与保存帧间功能，通过融合与血管造影和支架design.Methods和ResultsStrut的先验知识提取连续OCT帧。使用标准插值重建生成不连续的支架结构。通过计算约束插值到已知支架骨架，拟合OCT-血管造影衍生支柱的3D“云”，解决了植入物解剖结构，准确呈现了从植入物直径和曲率（n = 1血管，r（2）分别= 0.91，0.90）到单个支柱壁配置（平均位移误差类似于15 μ m）的特征。该框架促进了血流动力学模拟（n = 1血管），显示了准确的解剖渲染在表征定量和基本定性血流模式方面的至关重要性。标准方法的不连续性系统地引入了噪声和偏差，难以捕捉区域流动效应。相比之下，增强的方法保留多尺度（局部支柱区域支架）流的相互作用，证明了局部部署errors.ConclusionFusion的平面血管造影和设备设计的知识，在原位组织-设备相互作用的增强OCT图像分析中定义的血流动力学后果的区域背景的影响。鉴于模拟衍生的血流动力学评估作为生物风险的替代措施的新兴利益，这种融合的方式提供了一个新的窗口，进入患者特定的植入环境。
BackgroundStacking cross-sectional intravascular images permits three-dimensional rendering of endovascular implants, yet introduces between-frame uncertainties that limit characterization of device placement and the hemodynamic microenvironment. In a porcine coronary stent model, we demonstrate enhanced OCT reconstruction with preservation of betweenframe features through fusion with angiography and a priori knowledge of stent design.Methods and ResultsStrut positions were extracted from sequential OCT frames. Reconstruction with standard interpolation generated discontinuous stent structures. By computationally constraining interpolation to known stent skeletons fitted to 3D 'clouds' of OCT-Angio-derived struts, implant anatomy was resolved, accurately rendering features from implant diameter and curvature (n = 1 vessels, r(2) = 0.91, 0.90, respectively) to individual strut-wall configurations (average displacement error similar to 15 mu m). This framework facilitated hemodynamic simulation (n = 1 vessel), showing the critical importance of accurate anatomic rendering in characterizing both quantitative and basic qualitative flow patterns. Discontinuities with standard approaches systematically introduced noise and bias, poorly capturing regional flow effects. In contrast, the enhanced method preserved multi-scale (local strut to regional stent) flow interactions, demonstrating the impact of regional contexts in defining the hemodynamic consequence of local deployment errors.ConclusionFusion of planar angiography and knowledge of device design permits enhanced OCT image analysis of in situ tissue-device interactions. Given emerging interests in simulation-derived hemodynamic assessment as surrogate measures of biological risk, such fused modalities offer a new window into patient-specific implant environments.