Three weeks of early-onset exercise prolongs obesity resistance in DIO rats after exercise cessation.
Three weeks of early-onset exercise prolongs obesity resistance in DIO rats after exercise cessation.
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三周的早期运动可延长 DIO 大鼠停止运动后的肥胖抵抗力。
DOI：
10.1152/ajpregu.00661.2007
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Levin,BarryE
中科院分区：
文献类型：
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作者：
Patterson,ChristaM;Dunn-Meynell,AmbroseA;Levin,BarryE
我们评估了早发性运动作为预防儿童肥胖的一种手段的效果，使用选择性饲养的幼年雄性大鼠，以发展饮食诱导的肥胖症（DIO）或饮食抵抗（DR）时，喂食31%的脂肪高能量饮食。在36日龄时开始的自愿轮跑选择性地减少了DIO与DR大鼠的肥胖。其他4周龄的DIO大鼠喂食高能量饮食和运动（Ex）13周增加了他们的核心温度，体重增加了22%，与久坐（Sed）大鼠相比，脂肪垫轻了39%。当车轮被删除后6周（6周Ex/7周Sed），大鼠在未来的7周体重增加较少比Sed大鼠，仍然有可比的脂肪垫重量13周运动的大鼠。事实上，只有3周的运动足以防止肥胖10周后，车轮删除。最后，6-wk-Ex/7-wk-Sed大鼠与Sed大鼠相比，弓状核阿黑皮素原mRNA表达增加了55%，表明这有助于其持续的肥胖抵抗。最后，当Sed大鼠的热量限制为6周，以匹配他们的体重Ex大鼠（6周Rstr/7周铝），他们增加了他们的摄入量和体重时，随意喂养，7周后，有较高的瘦素水平和肥胖比Sed大鼠。因此，早发性运动可能会有利地改变，而早期的热量限制可能会不利地影响，下丘脑通路控制大脑发育过程中的能量稳态的发展。
We assessed the effect of early-onset exercise as a means of preventing childhood obesity using juvenile male rats selectively bred to develop diet-induced obesity (DIO) or to be diet resistant (DR) when fed a 31% fat high-energy diet. Voluntary wheel running begun at 36 days of age selectively reduced adiposity in DIO vs. DR rats. Other 4-wk-old DIO rats fed a high-energy diet and exercised (Ex) for 13 wk increased their core temperature, gained 22% less body weight, and had 39% lighter fat pads compared with sedentary (Sed) rats. When wheels were removed after 6 wk (6 wk Ex/7 wk Sed), rats gained less body weight over the next 7 wk than Sed rats and still had comparable adipose pad weights to 13-wk-exercised rats. In fact, only 3 wk of exercise sufficed to prevent obesity for 10 wk after wheel removal. Terminally, the 6-wk-Ex/7-wk-Sed rats had a 55% increase in arcuate nucleus proopiomelanocortin mRNA expression vs. Sed rats, suggesting that this contributed to their sustained obesity resistance. Finally, when Sed rats were calorically restricted for 6 wk to weight match them to Ex rats (6 wk Rstr/7 wk Al), they increased their intake and body weight when fed ad libitum and, after 7 wk more, had higher leptin levels and adiposity than Sed rats. Thus, early-onset exercise may favorably alter, while early caloric restriction may unfavorably influence, the development of the hypothalamic pathways controlling energy homeostasis during brain development.