Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children
Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children
复制标题
呼吸道病毒组和血清细胞因子谱的改变与儿童反复呼吸道感染相关
DOI：
10.1038/s41467-019-10294-x
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发表时间：
2019-05-23
影响因子：
16.6
通讯作者：
Zhang, Chiyu
中科院分区：
文献类型：
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作者：
Li, Yanpeng;Fu, Xuemin;Zhang, Chiyu
复发性急性呼吸道感染（ARTIs）影响了大量人群，但具体的决定性因素在很大程度上尚不清楚。我们研究了4407名确诊为阿尔蒂的儿童，比较了6年期间与多种ARTI和单一阿尔蒂相关的呼吸道病毒组和血清细胞因子谱。与单一阿尔蒂组相比，多个ARTI组中的丙酸杆菌相对丰度显著升高。与单一ARTI和非ARTI对照组相比，多发性ART患者的TIMP-1和PDGF-BB血清水平显著升高，这两种细胞因子成为多发性ART的潜在预测因子。丙酸杆菌的存在与较高水平的TIMP-1和PDGF-BB相关。受试者工作特征（ROC）曲线分析显示，TIMP-1、PDGF-BB和丙酸杆菌的组合可能是多种ART的强预测因子。这些发现表明，呼吸道微生物稳态和特定细胞因子与随着时间的推移发生的多种ARTs相关。
Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of Propionibacterium phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of Propionibacterium phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and Propionibacterium phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time.