Tumor density is associated with response to endobronchial ultrasound-guided transbronchial needle injection of cisplatin.
Tumor density is associated with response to endobronchial ultrasound-guided transbronchial needle injection of cisplatin.
复制标题
DOI：
10.21037/jtd-20-674
复制
发表时间：
2020-09
影响因子：
2.5
通讯作者：
Mehta H
中科院分区：
文献类型：
--
作者：
Kinsey CM;San José Estépar R;Bates JHT;Cole BF;Washko G;Jantz M;Mehta H
Endobronchial ultrasound-guided transbronchial needle injection of cisplatin (EBUS-TBNI cisplatin) is a therapeutic option for patients with recurrent lung cancer. However, the tumor characteristics that influence the distribution of the agent following intratumoral delivery remain largely unknown. We performed a retrospective evaluation of EBUS-TBNI cisplatin cases performed at two centers. Semi-automated tumor segmentation from CT scans was performed while blinded to the outcome of response. Twenty-four algorithmic radiomics features from two categories, Morphology (i.e., shape, volume) and Intensity (i.e., density), were extracted, and feature selection performed via least absolute shrinkage and selection operator (LASSO) regression. Models were constructed from clinicoepidemiologic variables and selected radiomics features and evaluated using the likelihood ratio chi-square assessment and Akaike’s information criterion (AIC). Thirty-eight patients with available imaging data were analyzed. Based on RECIST criteria, 27 of 38 treated sites demonstrated complete or partial remission (71%). The top three features identified by LASSO regression were variance, energy, and kurtosis. All three are measures of intensity, a surrogate for tumor density. Two logistic regression models with the outcome of response were created, each with the top 3 categorical features: (I) an Intensity model including variance, energy, and kurtosis, and (II) a Morphology model including surface-to-volume ratio, spherical disproportion, and maximum 3-dimensional (3D) diameter. Only the Intensity model met criteria for significance (P=0.024), and it resulted in a lower AIC and higher pseudo R square value vs. the Morphology model. Measures of tumor density are more highly associated with response to EBUS-TBNI cisplatin than measures of morphology.
登录
查看更多内容
影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
DOI：
10.1158/1078-0432.ccr-16-2821
发表时间：
2017-08-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Lee JM;Lee MH;Garon E;Goldman JW;Salehi-Rad R;Baratelli FE;Schaue D;Wang G;Rosen F;Yanagawa J;Walser TC;Lin Y;Park SJ;Adams S;Marincola FM;Tumeh PC;Abtin F;Suh R;Reckamp KL;Lee G;Wallace WD;Lee S;Zeng G;Elashoff DA;Sharma S;Dubinett SM
通讯作者：
Dubinett SM
DOI：
10.1056/nejmoa1007285
发表时间：
2011-03-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Washko GR;Hunninghake GM;Fernandez IE;Nishino M;Okajima Y;Yamashiro T;Ross JC;Estépar RS;Lynch DA;Brehm JM;Andriole KP;Diaz AA;Khorasani R;D'Aco K;Sciurba FC;Silverman EK;Hatabu H;Rosas IO;COPDGene Investigators
通讯作者：
COPDGene Investigators
影响因子：
11.2
作者：
van Griethuysen JJM;Fedorov A;Parmar C;Hosny A;Aucoin N;Narayan V;Beets-Tan RGH;Fillion-Robin JC;Pieper S;Aerts HJWL
通讯作者：
Aerts HJWL
影响因子：
5.3
作者：
Celikoglu, F;Celikoglu, SI;Goldberg, EP
通讯作者：
Goldberg, EP