Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence
Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence
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DOI：
10.1038/sj.mp.4000542
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发表时间：
1999-09-01
影响因子：
11
通讯作者：
MacMurray, JP
中科院分区：
文献类型：
--
作者：
Comings, DE;Gonzalez, N;MacMurray, JP
我们检验了多巴胺D-3受体基因（DRD3）是可卡因依赖的易感性因素的假设。在47名可卡因依赖的白种人和305名对照白种人中检测了DRD3基因的MscI/BalI多态性。基于先前对一系列精神疾病的研究，我们假设患者样本中12种基因型的频率会降低（纯合性增加）。我们观察到可卡因依赖者的12个杂合子频率（29.8%）显著低于对照组（46.9%）（P小于等于0.028）。在长期使用可卡因超过10年（25%）或超过15年（21.5%）的人群中，这一比例仍然更低。DRD3基因占可卡因依赖方差的1.64%。DRD2基因对可卡因依赖具有独立和累加作用。这些发现支持了DRD3基因在可卡因依赖易感性中的适度作用。
We examined the hypothesis that the dopamine D-3 receptor gene (DRD3) is a susceptibility factor for cocaine dependence. The MscI/BalI polymorphism of the DRD3 gene was examined in 47 Caucasian subjects with cocaine dependence and 305 Caucasian controls. Based on prior studies with a range of psychiatric disorders we hypothesized there would be a decrease in the frequency of the 12 genotype in the patient sample (increased homozygosity). We observed a significant decrease in the frequency of 12 heterozygotes in subjects with cocaine dependence (29.8%) vs controls (46.9%) (P less than or equal to 0.028). This percentage was still fewer in those who had chronically used cocaine for more than 10 years (25%), or more than 15 years (21.5%). The DRD3 gene accounted for 1.64% of the variance of cocaine dependence. The DRD2 gene had an independent and additive effect on cocaine dependence. These findings support a modest role of the DRD3 gene in susceptibility to cocaine dependence.