The Role of TP53 and MDM2 Polymorphisms in the Risk of Cervical Cancer
The Role of TP53 and MDM2 Polymorphisms in the Risk of Cervical Cancer
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TP53 和 MDM2 多态性在宫颈癌风险中的作用
DOI：
10.1166/asl.2012.3712
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发表时间：
2012-05
影响因子：
--
通讯作者：
Jiang, Pei,Li, Wen, Jianxin Tang*.
中科院分区：
文献类型：
--
作者：
Jiang, Pei,Li, Wen, Jianxin Tang*.
本研究的目的是确定TP 53 Arg 72 Pro和MDM 2 T309 G多态性变异是否与中国妇女宫颈癌风险增加相关，无论是单独还是联合。我们研究了TP 53和MDM 2基因的遗传多态性，在一项基于人群的病例对照研究中，有167例宫颈癌病例和223名对照。与TP 53 Pro/Pro或MDM 2 TT基因型相比，观察到TP 53 Arg/Arg（OR，2.47; 95% CI，1.25-4.87）或MDM 2 GG（OR，2.15; 95% CI，1.16-4.01）基因型与宫颈癌相关的风险增加。此外，检测到TP 53和MDM 2多态性在增加宫颈癌风险方面的联合作用，TP 53 Arg/Arg和MDM 2 309 GG基因型同时存在的比值比（OR）为3.43（95%CI，1.91-6.19）。提示TP 53和MDM 2基因多态性可能是中国妇女宫颈癌发病的遗传因素。
The objective of this study was to identify whether polymorphic variants of TP53 Arg72Pro and MDM2 T309G were associated with increased risk for cervical cancer, either independently or jointly among chinese women. We studied genetic polymorphisms in TP53 and MDM2 genes in a population-based case-control study with 167 cervical cancer cases and 223 controls. An increased risk of cervical cancer associated with the TP53 Arg/Arg (OR, 2.47; 95% CI, 1.25–4.87) or MDM2 GG (OR, 2.15; 95% CI, 1.16–4.01) genotype was observed compared with the TP53 Pro/Pro or MDM2 TT genotype, respectively. Additionally, a joint effect between the TP53 and MDM2 polymorphisms in intensifying cervical cancer risk was detected, with the odds ratio (OR) for the presence of both TP53 Arg/Arg and MDM2 309GG genotypes being 3.43 (95% CI, 1.91–6.19). These findings suggest that TP53 and MDM2 polymorphisms may be genetic determinants for the risk of cervical cancer among chinese women.