Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain.

Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain.
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抑制自噬通过激活大鼠大脑中的钙蛋白酶来引起 tau 蛋白水解。

DOI:
10.3233/jad-2009-0908
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发表时间:
2009
期刊:
Journal of Alzheimer's disease : JAD
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自噬性溶酶体系统有助于清除胞质成分,阿尔茨海默病(AD)患者脑中的溶酶体蛋白酶异常已被报道。然而,溶酶体在tau蛋白降解中的作用仍有待进一步研究。
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