Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain.
Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain.
复制标题
抑制自噬通过激活大鼠大脑中的钙蛋白酶来引起 tau 蛋白水解。
DOI:
10.3233/jad-2009-0908
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发表时间:
2009
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中科院分区:
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The autophagic lysosomal system contributes to the removal of cytosolic components, and abnormality of lysosomal proteases has been reported in the brain of patients with Alzheimer's disease (AD). However, the role of lysosome in tau degradation is still