Procalcitonin-guided antibiotic use in acute exacerbations of idiopathic pulmonary fibrosis.
Procalcitonin-guided antibiotic use in acute exacerbations of idiopathic pulmonary fibrosis.
复制标题
DOI：
10.7150/ijms.4972
复制
发表时间：
2013
影响因子：
3.6
通讯作者：
Feng K
中科院分区：
文献类型：
--
作者：
Ding J;Chen Z;Feng K
目的：探讨降钙素原在指导特发性肺纤维化急性加重期抗生素治疗中的临床价值。方法：将特发性肺纤维化急性加重患者随机分为降钙素原引导组（降钙素原阈值0.25 ng/ml指导下使用抗生素）和常规治疗组（按常规使用抗生素）。在基线和30天后对临床结果进行随访评估。结果：基线特征包括人口统计学、临床特征和实验室结果在两组之间相似。PCT指导导致抗生素治疗持续时间显著缩短（常规治疗组为8.7±6.6天，常规治疗组为14.2±5.2天）。与对照组（35例）相比，PCT组（26例）接受抗生素治疗的患者较少。两组治疗成功率、死亡率、住院天数和通气治疗相似。结论：降钙素原引导的特发性肺纤维化急性加重患者抗生素治疗可减少抗生素暴露，而不会对患者预后产生不良影响。
Object: To assess the clinical value of procalcitonin to guide antibiotic therapy in acute exacerbations of idiopathic pulmonary fibrosis. Methods: Patients with acute exacerbations of idiopathic pulmonary fibrosis were randomly assigned to the procalcitonin-guided group (antibiotic use guided by a procalcitonin threshold of 0.25 ng/ml) or the routine treatment group (antibiotic use according to routine practice). Follow up of clinical outcomes were assessed at baseline and 30 days later. Results: Baseline characteristics including demographics, clinical characteristics and laboratory results were similar between groups. PCT guidance resulted in a significant reduction of antibiotic treatment duration (8.7±6.6 compared to 14.2±5.2 days in the routine treatment group). Fewer patients were exposed to antibiotics treatment in the PCT group (26 patients) compared with the control group (35 patients). Treatment success, mortality rate, days of hospitalization and ventilation therapy were similar between the two groups. Conclusion: Procalcitonin-guided antibiotic therapy of patients with acute exacerbation of idiopathic pulmonary fibrosis may result in reduced exposure to antibiotics without adversely affecting patient outcomes.
登录
查看更多内容
DOI：
10.1164/rccm.200512-1922oc
发表时间：
2006-07-01
影响因子：
24.7
作者：
Christ-Crain, Miriam;Stolz, Daiana;Mueller, Beat
通讯作者：
Mueller, Beat
DOI：
10.1164/rccm.200708-1238oc
发表时间：
2008-03-01
影响因子：
24.7
作者：
Nobre, Vandack;Harbarth, Stephan;Pugin, Jerome
通讯作者：
Pugin, Jerome
影响因子：
2.3
作者：
Schroeder, S.;Hochreiter, M.;von Spiegel, T.
通讯作者：
von Spiegel, T.
影响因子：
9.6
作者：
Hyzy, Robert;Huang, Steven;Martinez, Fernando
通讯作者：
Martinez, Fernando
影响因子：
1.2
作者：
Horita, Nobuyuki;Akahane, Makiko;To, Yasuo
通讯作者：
To, Yasuo