Anterior cingulate cortex volume reduction in patients with panic disorder
Anterior cingulate cortex volume reduction in patients with panic disorder
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DOI：
10.1111/j.1440-1819.2008.01800.x
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发表时间：
2008-06-01
影响因子：
11.9
通讯作者：
Hirayasu, Yoshio
中科院分区：
文献类型：
--
作者：
Asami, Takeshi;Hayano, Fumi;Hirayasu, Yoshio
目的：最近的神经影像学研究表明，前扣带皮层（ACC）在惊恐障碍的病理中起重要作用。尽管许多功能性神经影像学研究已经阐明了前ACC的功能异常与惊恐障碍及其症状和对与惊恐障碍相关的情绪任务的反应之间的密切关系，但还没有研究显示前ACC或其子区域的体积变化。方法：采用感兴趣区（ROI）和优化体素形态学（VBM）相结合的方法，对26例惊恐障碍患者和26例年龄、性别匹配的健康受试者进行分析，以明确ACC及其亚区结构异常。在ROI研究中，ACC被分为四个亚区：背侧、吻侧、胼胝体下和亚膝ACC。结果：人工追踪的ROI体积比较结果显示右侧ACC背侧体积明显减少。VBM还显示右侧背侧以及部分吻侧ACC的体积减少为复合肿块。结论：人工ROI追踪和优化的VBM均提示惊恐障碍患者ACC体积缺损的亚区域特异性模式。除了功能异常外，这些结果表明ACC的结构异常有助于惊恐障碍的病理生理。
Aim: Recent neuroimaging studies have suggested that the anterior cingulate cortex (ACC) has an important role in the pathology of panic disorder. Despite numerous functional neuroimaging studies that have elucidated the strong relationship between functional abnormalities of the ACC and panic disorder and its symptoms and response to emotional tasks associated with panic disorder, there has been no study showing volumetric changes of the ACC or its subregions.Methods: To clarify the structural abnormalities of ACC and its subregions, the combination of region of interest (ROI) and optimized voxel-based morphometry (VBM) methods were performed on 26 patients with panic disorder, and 26 age and sex-matched healthy subjects. In the ROI study, ACC was divided into four subregions: dorsal, rostral, subcallosal and subgenual ACC.Results: The results of the manually traced ROI volume comparison showed significant volume reduction in the right dorsal ACC. VBM also showed a volume reduction in the right dorsal as well as a part of the rostral ACC as a compound mass.Conclusions: Both manual ROI tracing and optimized VBM suggest a subregion-specific pattern of ACC volume deficit in panic disorder. In addition to functional abnormalities, these results suggest that structural abnormalities of the ACC contribute to the pathophysiology of panic disorder.