Quality of life after radical prostatectomy in Japanese men: 2 year longitudinal study.
Quality of life after radical prostatectomy in Japanese men: 2 year longitudinal study.
复制标题
日本男性根治性前列腺切除术后的生活质量：2 年纵向研究。
DOI：
10.1093/jjco/hyi145
复制
发表时间：
2005
影响因子：
2.4
通讯作者：
Y. Arai
中科院分区：
文献类型：
--
作者：
S. Namiki;S. Saito;M. Satoh;S. Ishidoya;Sadafumu Kawamura;T. Tochigi;M. Kuwahara;M. Aizawa;N. Ioritani;K. Yoshimura;K. Ichioka;A. Terai;Y. Arai
目标
我们对患有局限性前列腺癌的日本男性进行根治性耻骨后前列腺切除术 (RP) 后的健康相关生活质量 (HRQOL) 进行了为期 2 年的纵向调查。
患者和方法
我们对 112 名接受 RP 治疗的患者进行了术前和术后 3、6、12、18 和 24 个月的 SF-36 和加州大学洛杉矶分校前列腺癌指数测量。
结果
接受 RP 的患者在一般 HRQOL 的某些领域表现出问题，但这些问题随着时间的推移而减少。在整个随访期间，心理健康状况显着改善。 3个月时排尿功能大幅下降，随后逐渐恢复，但从未恢复到基线。 3 个月时排尿困难显着减少，但 6 个月时恢复到基线。 RP后性功能和性困扰的数据显示得分大幅降低。患者在术后期间明显丧失性欲。 12个月后，保留神经组的性功能改善明显优于非保留神经组，并且这种改善持续到术后2年。
结论
尽管有报道称存在性行为和尿失禁问题，但 6 个月后一般 HRQOL 基本不受 RP 影响。 RP 对心理健康有积极的影响。尽管排尿功能即使在 RP 后 2 年也没有完全恢复到基线水平，但排尿障碍恢复得很快。 RP 对性欲、勃起功能和性活动产生严重影响。第二年，接受双侧神经保留手术的 RP 患者的性功能继续改善。
OBJECTIVE
We performed a 2 year longitudinal survey of health-related quality of life (HRQOL) after radical retropubic prostatectomy (RP) in Japanese men with localized prostate cancer.
PATIENTS AND METHODS
We measured 112 patients who underwent RP with SF-36 and University of California, Los Angeles Prostate Cancer Index before and 3, 6, 12, 18 and 24 months after surgery.
RESULTS
Patients who underwent RP showed problems in some domains of general HRQOL, but these problems diminished over time. Mental health significantly improved throughout the follow-up period. The urinary function substantially declined at 3 months and continued to recover gradually but never returned to the baseline. Urinary bother at 3 months showed a significant decrease, but at 6 months it returned to baseline. The data of sexual function and bother showed a substantially lower score after RP. Patients lost their sexual desire significantly throughout the post-operative period. After 12 months, the nerve sparing group had significantly better improvement in sexual function than the non-nerve sparing group and this improvement continued up to 2 years after operation.
CONCLUSION
Despite reports of problems with sexuality and urinary continence, general HRQOL was mostly unaffected by RP after 6 months. RP had a favorable impact on mental health. Although urinary function did not completely return to the baseline level even at 2 years after RP, recovery from urinary bother was rapid. RP had serious consequences on libido, erectile function and sexual activity. In the second year, the sexual function of those who underwent RP with bilateral nerve sparing procedure continued to improve.
早期前列腺癌主要治疗后患者报告的症状：前瞻性队列研究的结果。
DOI：
10.1200/jco.1998.16.1.275
发表时间：
1998
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Talcott,JA;Rieker,P;Clark,JA;Propert,KJ;Weeks,JC;Beard,CJ;Wishnow,KI;Kaplan,I;Loughlin,KR;Richie,JP;Kantoff,PW
通讯作者：
Kantoff,PW