The Macula Flava of the Human Vocal Fold as a Stem Cell Microenvironment
The Macula Flava of the Human Vocal Fold as a Stem Cell Microenvironment
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DOI：
10.1007/978-3-319-69194-7_9
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发表时间：
2017-01-01
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影响因子：
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通讯作者：
Sato, Kiminori
中科院分区：
文献类型：
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作者：
Sato, Kiminori
1. 越来越多的证据表明，黄斑中的细胞是人类声带的组织干细胞，黄斑是干细胞生态位的候选者。2．最新研究表明，人黄斑中的细胞参与细胞外基质的代谢，而细胞外基质对人声带粘膜作为振动组织的粘弹性至关重要，被认为是人声带粘膜生长、发育和衰老过程中的重要细胞。 3．人黄斑细胞含有全部三个胚层的蛋白质，表明它们是未分化的，具有多能性。 4．人类黄斑中的细胞分裂反映了不对称的自我更新，培养的细胞形成集落形成单位。因此，这种现象表明人黄斑中的细胞很可能是组织干细胞。 5．最近的研究表明，人黄斑中的细胞是由骨髓细胞通过外周循环分化产生的。6．黄斑中的透明质酸浓度较高，并且含有具有透明质酸受体的细胞，表明黄斑是富含透明质酸的基质，这是干细胞生态位所必需的。7．人类声带粘膜黄斑中适当的微环境对于有效地作为干细胞生态位维持所含组织干细胞的干性是必要的。
1. There is growing evidence to suggest that the cells in the maculae flavae are tissue stem cells of the human vocal fold and maculae flavae are a candidate for a stem cell niche.2. The latest research shows that the cells in the human maculae flavae are involved in the metabolism of extracellular matrices that are essential for the viscoelasticity in the human vocal fold mucosa as a vibrating tissue, and considered to be important cells in the growth, development, and aging of the human vocal fold mucosa.3. The cells in the human maculae flavae possess proteins of all three germ layers, indicating they are undifferentiated and have the ability of multipotency.4. The cell division in the human adult maculae flavae is reflective of asymmetric self-renewal and cultured cells form a colony-forming unit. Therefore, the phenomenon gives rise to the strong possibility that the cells in the human maculae flavae are tissue stem cells.5. Recent research suggests that the cells in the human maculae flavae arise from the differentiation of bone marrow cells via peripheral circulation.6. The hyaluronan concentration in the maculae flavae is high and contains cells which possess hyaluronan receptors, indicating that the maculae flavae are hyaluronan- rich matrix, which is required for a stem cell niche.7. A proper microenvironment in the maculae flavae of the human vocal fold mucosa is necessary to be effective as a stem cell niche maintaining the stemness of the contained tissue stem cells.