Regularized approach for data missing not at random.

Regularized approach for data missing not at random.
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DOI:
10.1177/0962280217717760
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发表时间:
2019-01
影响因子:
2.3
通讯作者:
Chen YH
Chen YH
中科院分区:
医学3区
文献类型:
--
作者:
Tseng CH;Chen YH

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It is common in longitudinal studies that missing data occur due to subjects’ no response, missed visits, dropout, death or other reasons during the course of study. To perform valid analysis in this setting, data missing not at random (MNAR) have to be considered. However, models for data MNAR often suffer from the identifiability issue and hence result in difficulty in estimation and computational convergence. To ameliorate this issue, we propose the LASSO and Ridge regularized selection models that regularize the missing data mechanism model to handle data MNAR, with the regularization parameter selected via a cross validation procedure. The proposed models can be also employed for sensitivity analysis to examine the effects on inference of different assumptions about the missing data mechanism. We illustrate the performance of the proposed models via simulation studies and the analysis of data from a randomized clinical trial.
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