Impaired Reproduction of Three-Dimensional Objects by Cocaine-Dependent Subjects
Impaired Reproduction of Three-Dimensional Objects by Cocaine-Dependent Subjects
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DOI：
10.1176/appi.neuropsych.20.4.478
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发表时间：
2008-09-01
影响因子：
2.9
通讯作者：
Pitman, Roger K.
中科院分区：
文献类型：
--
作者：
Elman, Igor;Chi, Won H.;Pitman, Roger K.
本研究采用图形复制的知觉运动任务在27可卡因依赖，26大麻滥用或依赖，和33名健康受试者。可卡因依赖者和健康个体在复制二维菱形和十字形的得分上没有差异。相比之下，可卡因依赖的受试者表现出明显较差的能力复制三维内克尔立方体，吸烟管，隐藏线消除立方体，金字塔和解剖金字塔。玛丽安娜使用者在所有复制图上的表现与健康的对照受试者相当。考虑到已发现三维复制能力下降与致命伤害有关，需要进一步研究来调查可能的潜在机制（例如，顶叶损伤）及其在可卡因依赖的病理生理学中的作用。
This study employed a perceptual-motor task of figure copying in 27 cocaine-dependent, 26 marijuana-abusing or dependent, and 33 healthy subjects. Cocaine-dependent and healthy individuals did not differ in their scores on the copying of a two-dimensional diamond and a cross. In contrast, cocaine-dependent subjects displayed significantly poorer ability to copy a three-dimensional Necker cube, a smoking pipe, a hidden line elimination cube, a pyramid, and a dissected pyramid. Marijuana users' performance on all copied figures was comparable to that of the healthy comparison subjects. Considering that decreased three-dimensional copying ability has been found to be associated with fatal injuries, further studies are needed to investigate possible underlying mechanisms (e.g., parietal lobe damage) and their role in the pathophysiology of cocaine dependence.