It takes a village: constructing the neurogenic niche.
It takes a village: constructing the neurogenic niche.
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DOI：
10.1016/j.devcel.2015.01.010
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发表时间：
2015-02-23
影响因子：
11.8
通讯作者：
Temple S
中科院分区：
文献类型：
--
作者：
Bjornsson CS;Apostolopoulou M;Tian Y;Temple S
虽然发育过程中和成人中神经发生的许多特征是神经发生细胞本身固有的，但微环境的作用是无可辩驳的。神经源性生态位是影响中枢神经系统发育的细胞和因素的大熔炉。不同的元素如何组合，何时组合？在胚胎发育和成年期间，生态位在结构和功能上是如何变化的？在这篇综述中，我们将重点关注参与神经源性生态位的非神经细胞的影响，强调不同胚胎来源的细胞如何影响这一关键的生发空间。
While many features of neurogenesis during development and in the adult are intrinsic to the neurogenic cells themselves, the role of the microenvironment is irrefutable. The neurogenic niche is a melting pot of cells and factors that influence CNS development. How do the diverse elements assemble, and when? How does the niche change structurally and functionally during embryogenesis and into adulthood? In this review, we focus on the impact of non-neural cells that participate in the neurogenic niche, highlighting how cells of different embryonic origins influence this critical germinal space.