DO ACETYLCHOLINE RECEPTOR AND STRIATED MUSCLE ANTIBODIES PREDICT THE PRESENCE OF THYMOMA IN PATIENTS WITH MYASTHENIA GRAVIS?
DO ACETYLCHOLINE RECEPTOR AND STRIATED MUSCLE ANTIBODIES PREDICT THE PRESENCE OF THYMOMA IN PATIENTS WITH MYASTHENIA GRAVIS?
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DOI：
10.1002/mus.23882
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发表时间：
2014-01-01
期刊：
影响因子：
3.4
通讯作者：
Sanders, Donald B.
中科院分区：
文献类型：
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作者：
Decroos, Emily Choi;Hobson-Webb, Lisa D.;Sanders, Donald B.
简介：乙酰胆碱受体（AChR）和横纹肌抗体（StrAbs）在合并胸腺瘤的重症肌无力（MG）患者中常见。在本研究中，我们的目的是确定这些抗体对MG患者胸腺瘤的阳性预测值（PPV）和阴性预测值（NPV）。方法：对1141例MG患者的抗体检测结果、胸腺组织学和发病年龄进行回顾性分析。测定了这些胸腺瘤抗体的PPV和NPV。结果：AChR结合抗体+StrAb阳性率最高（50.0%），发病年龄在40岁以前。所有抗体的PPV均较低（
Introduction: Acetylcholine receptor (AChR) and striated muscle antibodies (StrAbs) are found frequently in myasthenia gravis (MG) patients with thymoma. In this study we aimed to determine the positive predictive value (PPV) and negative predictive value (NPV) of these antibodies for thymoma in patients with MG. Methods: Antibody findings, thymic histology, and onset age were reviewed for 1141 patients with MG. PPV and NPV of these antibodies for thymoma were determined. Results: The PPV of AChR binding antibodies plus StrAbs was highest (50.0%) with onset before the age of 40 years. The PPV of all antibodies was low (