Gaze-triggered orienting is reduced in chronic schizophrenia
Gaze-triggered orienting is reduced in chronic schizophrenia
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DOI：
10.1016/j.psychres.2006.12.004
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发表时间：
2008-04-15
影响因子：
11.3
通讯作者：
Kashima, Haruo
中科院分区：
文献类型：
--
作者：
Akiyama, Tomoko;Kato, Motoichiro;Kashima, Haruo
据报道，精神分裂症患者在凝视处理中表现出轻微的损伤，在某些情况下，这表明对凝视敏感，而在其他情况下，敏感性降低。注视加工的神经相关区位于颞上沟（上级temporal sulcus，STS），其主要部分由颞上回（上级temporal gyrus，STG）构成，可能是精神分裂症注视敏感性异常的神经基础。为了确定慢性精神分裂症患者的凝视行为特征，据报道STG的体积较小，我们测试了22例患者（平均患病时间29年），在空间线索范式中使用两个中央图形凝视线索，这两个线索都有效地触发了22个年龄匹配的正常对照组的注意定向。箭头线索也被用来确定是否有任何妥协精神分裂症，如果存在，是凝视特异性。结果表明，精神分裂症的主题受益显着低于正常人的一致性线索，这是明显的凝视线索，但不是箭头线索。这一发现提示慢性精神分裂症患者存在相对的凝视特异性低敏感性，这一发现与他们的临床表现一致，可能与低活性STS相关。(C)2006爱思唯尔爱尔兰有限公司保留所有权利。
Patients with schizophrenia have been reported to demonstrate subtle impairment in gaze processing, which in some cases indicates hypersensitivity to gaze, while in others, hyposensitivity. The neural correlate of gaze processing is situated in the superior temporal sulcus (STS), a major portion of which is constituted by the superior temporal gyrus (STG), and may be the underlying dysfunctional neural basis to the abnormal gaze sensitivity in schizophrenia. To identify the characteristics of gaze behavior in patients with chronic schizophrenia, in whom the STG has been reported to be smaller in volume, we tested 22 patients (mean duration of illness 29 years) in a spatial cueing paradigm using two central pictorial gaze cues, both of which effectively triggered attentional orienting in 22 age-matched normal controls. Arrow cues were also employed to determine whether any compromise in schizophrenia, if present, was gaze-specific. Results demonstrated that schizophrenic subjects benefit significantly less from congruent cues than normal subjects, which was evident for gaze cues but not for arrow cues. This finding is suggestive of a relatively gaze-specific hyposensitivity in patients with chronic schizophrenia, a finding that is in line with their clinical symptomatology and that may be associated with a hypoactive STS. (C) 2006 Elsevier Ireland Ltd. All rights reserved.