Plasma intestinal fatty acid binding protein in neonates with necrotizing entercolitis: A pilot study
Plasma intestinal fatty acid binding protein in neonates with necrotizing entercolitis: A pilot study
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DOI：
10.1016/s0022-3468(99)90102-1
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发表时间：
1999-10-01
影响因子：
2.4
通讯作者：
Rozycki, HJ
中科院分区：
文献类型：
--
作者：
Edelson, MB;Sonnino, RE;Rozycki, HJ
背景/目的：肠脂肪酸结合蛋白（IFABP）存在于肠绒毛顶端的细胞内，这是坏死性小肠结肠炎（NEC）发生时通常受损的区域。进行这项研究，以确定如果测量IFABP浓度在血液中的早期NEC的过程中将区分患者的严重程度之前，临床结果表明，谁有阶段3 NEC和谁有温和的stages.Methods：三个血浆样本从新生儿评价NEC获得症状发作后8和24小时。用放射免疫法测定IFABP浓度。婴儿进行了分类的NEC的最后和最严重的阶段，IFABP水平进行了比较组之间在每个sampling.Results：IFABP是可检测的血液样本从所有7名婴儿阶段3 NEC相比，24个阶段1或2 NEC。7例3期NEC患者中有5例在临床分期前血浆IFABP水平升高。结论：IFABP可作为早期诊断NEC的特异性标志物。J Pediatr Surg 34：1453-1457版权所有（C）1999，W.B.桑德斯公司
Background/Purpose: Intestinal fatty acid-binding protein (IFABP) is found within cells at the tip of the intestinal villi, an area commonly injured when necrotizing enterocolitis (NEC) occurs. This study was undertaken to determine if measuring IFABP concentrations in the bloodstream early in the course of NEC would differentiate patients by severity before clinical findings made it clear who had stage 3 NEC and who had milder stages.Methods:Three plasma samples from newborn infants evaluated for NEC were obtained at symptom onset and after 8 and 24 hours. IFABP concentration was measured by radioimmunoassay. Infants were classified by the final and most severe stage of NEC, and IFABP levels were compared between groups at each sampling.Results: IFABP was detectable in blood samples from all 7 infants with stage 3 NEC compared with 3 of 24 with stages 1 or 2 NEC. Elevated plasma IFABP concentrations were detectable before clinical staging could be made in 5 of the 7 subjects with stage 3 NEC.Conclusion: IFABP may be a specific marker for early identification of severe NEC. J Pediatr Surg 34:1453-1457 Copyright (C) 1999 by W.B. Saunders Company.